Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency

Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency

Gentamicin is a used antibiotic that causes nephrotoxicity in 10–20% of treatment periods, which limits its use considerably. Our results have shown that cilastatin may be a promising therapeutic alternative in toxin-induced acute kidney injury (AKI). Here, we investigated its potential use as a nep...

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Bibliographic Details
Main Authors: Juan Carlos Jado, Blanca Humanes, María Ángeles González-Nicolás, Sonia Camaño, José Manuel Lara, Beatriz López, Emilia Cercenado, Julio García-Bordas, Alberto Tejedor, Alberto Lázaro
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
cilastatin
acute kidney injury
nephrotoxicity
nephroprotection
apoptosis
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/9/9/821

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