RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.

Hydrocarbon oils are often utilized as adjuvants in vaccines. In response to naturally occurring hydrocarbon oils, inflammation is initiated and persists with the continuous recruitment of immune cells such as macrophages and neutrophils. However, the mechanism underlying the chronic inflammation in...

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Main Authors: Qi Wu, Xin Sun, Ruo Chi, Long Xu, Xue Li, Jing Feng, Huaiyong Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3829825?pdf=render
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spelling doaj-42e735a912ab4c7c80b29657d02d9afc2020-11-24T21:16:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7949710.1371/journal.pone.0079497RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.Qi WuXin SunRuo ChiLong XuXue LiJing FengHuaiyong ChenHydrocarbon oils are often utilized as adjuvants in vaccines. In response to naturally occurring hydrocarbon oils, inflammation is initiated and persists with the continuous recruitment of immune cells such as macrophages and neutrophils. However, the mechanism underlying the chronic inflammation in response to hydrocarbon oils is not fully defined. In this study, we revealed an essential role of retinoid-related orphan receptor gamma t (RORγt) in sustaining the recruitment of macrophages following pristane treatment. RORγt absence resulted in the incompetent formation of mesenteric oil granulomas which may associate to a reduction in the migration of macrophages into the mesentery during pristane-induced inflammation. This is at least partially dependent on the expression of the monocyte chemoattractant protein-1 (MCP-1) in the mesentery and the decrease in the macrophage reservoir in the spleen. However, the absence of RORγt had no impact on the recruitment of neutrophils to the mesentery after pristane treatment. Our data uncovered an important role of RORγt in the recruitment of macrophages during hydrocarbon oil-induced chronic inflammation.http://europepmc.org/articles/PMC3829825?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Qi Wu
Xin Sun
Ruo Chi
Long Xu
Xue Li
Jing Feng
Huaiyong Chen
spellingShingle Qi Wu
Xin Sun
Ruo Chi
Long Xu
Xue Li
Jing Feng
Huaiyong Chen
RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.
PLoS ONE
author_facet Qi Wu
Xin Sun
Ruo Chi
Long Xu
Xue Li
Jing Feng
Huaiyong Chen
author_sort Qi Wu
title RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.
title_short RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.
title_full RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.
title_fullStr RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.
title_full_unstemmed RORγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.
title_sort rorγt modulates macrophage recruitment during a hydrocarbon oil-induced inflammation.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description Hydrocarbon oils are often utilized as adjuvants in vaccines. In response to naturally occurring hydrocarbon oils, inflammation is initiated and persists with the continuous recruitment of immune cells such as macrophages and neutrophils. However, the mechanism underlying the chronic inflammation in response to hydrocarbon oils is not fully defined. In this study, we revealed an essential role of retinoid-related orphan receptor gamma t (RORγt) in sustaining the recruitment of macrophages following pristane treatment. RORγt absence resulted in the incompetent formation of mesenteric oil granulomas which may associate to a reduction in the migration of macrophages into the mesentery during pristane-induced inflammation. This is at least partially dependent on the expression of the monocyte chemoattractant protein-1 (MCP-1) in the mesentery and the decrease in the macrophage reservoir in the spleen. However, the absence of RORγt had no impact on the recruitment of neutrophils to the mesentery after pristane treatment. Our data uncovered an important role of RORγt in the recruitment of macrophages during hydrocarbon oil-induced chronic inflammation.
url http://europepmc.org/articles/PMC3829825?pdf=render
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