Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practice
Abstract Background To evaluate the change in best corrected visual acuity (VA) and central macular thickness (CMT) following treatment with intravitreal aflibercept (AFL) in patients poorly responders or non responders to ranibizumab (RBZ). Methods Charts of patients injected with RBZ from January...
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doaj-42eb4cc619d4407fb9c26fb685cf680f2021-04-02T17:58:39ZengBMCInternational Journal of Retina and Vitreous2056-99202020-05-01611810.1186/s40942-020-00212-5Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practiceLuciana de Sá Quirino-Makarczyk0Maria de Fátima Sainz Ugarte1Bruna Viana Vieira2Sérgio Kniggendorf3Caio Vinicius Saito Regatieri4Department of Retina and Vitreous of Hospital Oftalmológico de BrasíliaHospital Oftalmológico de BrasíliaHospital Oftalmológico de BrasíliaDepartment of Retina and Vitreous of Hospital Oftalmológico de BrasíliaFederal University of São Paulo (UNIFESP)Abstract Background To evaluate the change in best corrected visual acuity (VA) and central macular thickness (CMT) following treatment with intravitreal aflibercept (AFL) in patients poorly responders or non responders to ranibizumab (RBZ). Methods Charts of patients injected with RBZ from January 2016 to December 2018 (548 cases) due to neovascular age-related macular degeneration (nAMD) were reviewed. Fifty-six cases met our criteria for poor responders to RBZ (CMT decreased between 5 and 15% over treatment) or for non responders to RBZ (CMT decreased less than 5% or increased over treatment). Results After the third AFL injection, CMT decreased from 384.38 ± 123.20 μm to 296.18 ± 70.52 μm in the non-responder group and from 320.00 ± 82.05 μm to 282.27 ± 56.86 μm in the poor responder group. Although decrease in macular thickness was overall achieved 3 months after switching to AFL, it was not translated in VA improvement. Conclusions it was observed that nAMD patients classified as RBZ non-responders tend to respond better to AFL than RBZ poor-responders anatomically, without correspondent improvement in VA.http://link.springer.com/article/10.1186/s40942-020-00212-5AfliberceptRanibizumabAge-related macular degenerationVascular endothelial growth factor |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luciana de Sá Quirino-Makarczyk Maria de Fátima Sainz Ugarte Bruna Viana Vieira Sérgio Kniggendorf Caio Vinicius Saito Regatieri |
spellingShingle |
Luciana de Sá Quirino-Makarczyk Maria de Fátima Sainz Ugarte Bruna Viana Vieira Sérgio Kniggendorf Caio Vinicius Saito Regatieri Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practice International Journal of Retina and Vitreous Aflibercept Ranibizumab Age-related macular degeneration Vascular endothelial growth factor |
author_facet |
Luciana de Sá Quirino-Makarczyk Maria de Fátima Sainz Ugarte Bruna Viana Vieira Sérgio Kniggendorf Caio Vinicius Saito Regatieri |
author_sort |
Luciana de Sá Quirino-Makarczyk |
title |
Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practice |
title_short |
Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practice |
title_full |
Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practice |
title_fullStr |
Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practice |
title_full_unstemmed |
Short-term results of early switch from Ranibizumab to Aflibercept in poor or non responder age related macular degeneration in clinical practice |
title_sort |
short-term results of early switch from ranibizumab to aflibercept in poor or non responder age related macular degeneration in clinical practice |
publisher |
BMC |
series |
International Journal of Retina and Vitreous |
issn |
2056-9920 |
publishDate |
2020-05-01 |
description |
Abstract Background To evaluate the change in best corrected visual acuity (VA) and central macular thickness (CMT) following treatment with intravitreal aflibercept (AFL) in patients poorly responders or non responders to ranibizumab (RBZ). Methods Charts of patients injected with RBZ from January 2016 to December 2018 (548 cases) due to neovascular age-related macular degeneration (nAMD) were reviewed. Fifty-six cases met our criteria for poor responders to RBZ (CMT decreased between 5 and 15% over treatment) or for non responders to RBZ (CMT decreased less than 5% or increased over treatment). Results After the third AFL injection, CMT decreased from 384.38 ± 123.20 μm to 296.18 ± 70.52 μm in the non-responder group and from 320.00 ± 82.05 μm to 282.27 ± 56.86 μm in the poor responder group. Although decrease in macular thickness was overall achieved 3 months after switching to AFL, it was not translated in VA improvement. Conclusions it was observed that nAMD patients classified as RBZ non-responders tend to respond better to AFL than RBZ poor-responders anatomically, without correspondent improvement in VA. |
topic |
Aflibercept Ranibizumab Age-related macular degeneration Vascular endothelial growth factor |
url |
http://link.springer.com/article/10.1186/s40942-020-00212-5 |
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