Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone Agonist
Objective: Gonadotropin-releasing hormone agonist (GnRH agonist) therapy has been useful as an adjunct before myomectomy or hysterectomy for uterine myoma. Case Report: A 26-year-old woman without sexual exposure was diagnosed with a submucosal myoma and treated with long-acting GnRH agonist. This p...
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doaj-42ed8622331b479ab248cd724f6b7b062020-11-25T01:08:30ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592006-06-0145217317510.1016/S1028-4559(09)60220-5Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone AgonistLily Wen0Jen-Yu Tseng1Peng-Hui Wang2Department of Obstetrics and Gynecology, Cardinal Tien Hospital-Hsintien, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Cardinal Tien Hospital-Hsintien, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, and Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, TaiwanObjective: Gonadotropin-releasing hormone agonist (GnRH agonist) therapy has been useful as an adjunct before myomectomy or hysterectomy for uterine myoma. Case Report: A 26-year-old woman without sexual exposure was diagnosed with a submucosal myoma and treated with long-acting GnRH agonist. This patient exhibited heavy menstruation and severe anemia for 2 years and consulted our outpatient department. Transabdominal ultrasound demonstrated a 3.5-cm submucosal myoma within the endometrial cavity. The patient showed a marked suppression of serum estradiol concentrations throughout the treatment (< 20 pg/mL at the second dose injection). The volume of the uterus and uterine myoma decreased to two-thirds of the original size at the end of the second dose injection. However, a sudden onset of severe abdominal cramping pain occurred on the 76th day and a ping-pong sized mass was expelled from the vagina. She visited our outpatient department for evaluation, where ultrasound failed to detect the previous submucosal uterine myoma. A 3-year follow-up has been uneventful. Conclusion: Spontaneous expulsion of submucosal myomas might occur after the administration of GnRH agonist; hence, it may be an acceptable alternative for symptomatic females without sexual exposure.http://www.sciencedirect.com/science/article/pii/S1028455909602205gonadotropin-releasing hormone agonistspontaneous expulsion submucosal myoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lily Wen Jen-Yu Tseng Peng-Hui Wang |
spellingShingle |
Lily Wen Jen-Yu Tseng Peng-Hui Wang Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone Agonist Taiwanese Journal of Obstetrics & Gynecology gonadotropin-releasing hormone agonist spontaneous expulsion submucosal myoma |
author_facet |
Lily Wen Jen-Yu Tseng Peng-Hui Wang |
author_sort |
Lily Wen |
title |
Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone Agonist |
title_short |
Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone Agonist |
title_full |
Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone Agonist |
title_fullStr |
Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone Agonist |
title_full_unstemmed |
Vaginal Expulsion of a Submucosal Myoma During Treatment with Long-Acting Gonadotropin-Releasing Hormone Agonist |
title_sort |
vaginal expulsion of a submucosal myoma during treatment with long-acting gonadotropin-releasing hormone agonist |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2006-06-01 |
description |
Objective: Gonadotropin-releasing hormone agonist (GnRH agonist) therapy has been useful as an adjunct before myomectomy or hysterectomy for uterine myoma.
Case Report: A 26-year-old woman without sexual exposure was diagnosed with a submucosal myoma and treated with long-acting GnRH agonist. This patient exhibited heavy menstruation and severe anemia for 2 years and consulted our outpatient department. Transabdominal ultrasound demonstrated a 3.5-cm submucosal myoma within the endometrial cavity. The patient showed a marked suppression of serum estradiol concentrations throughout the treatment (< 20 pg/mL at the second dose injection). The volume of the uterus and uterine myoma decreased to two-thirds of the original size at the end of the second dose injection. However, a sudden onset of severe abdominal cramping pain occurred on the 76th day and a ping-pong sized mass was expelled from the vagina. She visited our outpatient department for evaluation, where ultrasound failed to detect the previous submucosal uterine myoma. A 3-year follow-up has been uneventful.
Conclusion: Spontaneous expulsion of submucosal myomas might occur after the administration of GnRH agonist; hence, it may be an acceptable alternative for symptomatic females without sexual exposure. |
topic |
gonadotropin-releasing hormone agonist spontaneous expulsion submucosal myoma |
url |
http://www.sciencedirect.com/science/article/pii/S1028455909602205 |
work_keys_str_mv |
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