Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression

Cancer cells can affect cancer progression by producing systemic effects. Here, the authors show that IGF2 produced by oesophageal cancer cells increases secretion of VEGF from cancer-associated fibroblasts resulting in systemic mobilization of bone marrow-derived cells and increased metastases.

Bibliographic Details
Main Authors:	Wen Wen Xu, Bin Li, Xin Yuan Guan, Sookja K. Chung, Yang Wang, Yim Ling Yip, Simon Y. K. Law, Kin Tak Chan, Nikki P. Y. Lee, Kwok Wah Chan, Li Yan Xu, En Min Li, Sai Wah Tsao, Qing-Yu He, Annie L. M. Cheung
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14399

id	doaj-42f1fba27d344814905048b4a4333e89
record_format	Article
spelling	doaj-42f1fba27d344814905048b4a4333e892021-05-11T07:43:03ZengNature Publishing GroupNature Communications2041-17232017-02-018111710.1038/ncomms14399Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progressionWen Wen Xu0Bin Li1Xin Yuan Guan2Sookja K. Chung3Yang Wang4Yim Ling Yip5Simon Y. K. Law6Kin Tak Chan7Nikki P. Y. Lee8Kwok Wah Chan9Li Yan Xu10En Min Li11Sai Wah Tsao12Qing-Yu He13Annie L. M. Cheung14School of Biomedical Sciences, Li Ka Shing Faculty of MedicineSchool of Biomedical Sciences, Li Ka Shing Faculty of MedicineCentre for Cancer Research, Li Ka Shing Faculty of MedicineSchool of Biomedical Sciences, Li Ka Shing Faculty of MedicineCollege of Life Science and Technology, Jinan UniversitySchool of Biomedical Sciences, Li Ka Shing Faculty of MedicineCentre for Cancer Research, Li Ka Shing Faculty of MedicineCentre for Cancer Research, Li Ka Shing Faculty of MedicineCentre for Cancer Research, Li Ka Shing Faculty of MedicineCentre for Cancer Research, Li Ka Shing Faculty of MedicineThe Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical CollegeThe Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical CollegeSchool of Biomedical Sciences, Li Ka Shing Faculty of MedicineCollege of Life Science and Technology, Jinan UniversitySchool of Biomedical Sciences, Li Ka Shing Faculty of MedicineCancer cells can affect cancer progression by producing systemic effects. Here, the authors show that IGF2 produced by oesophageal cancer cells increases secretion of VEGF from cancer-associated fibroblasts resulting in systemic mobilization of bone marrow-derived cells and increased metastases.https://doi.org/10.1038/ncomms14399
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wen Wen Xu Bin Li Xin Yuan Guan Sookja K. Chung Yang Wang Yim Ling Yip Simon Y. K. Law Kin Tak Chan Nikki P. Y. Lee Kwok Wah Chan Li Yan Xu En Min Li Sai Wah Tsao Qing-Yu He Annie L. M. Cheung
spellingShingle	Wen Wen Xu Bin Li Xin Yuan Guan Sookja K. Chung Yang Wang Yim Ling Yip Simon Y. K. Law Kin Tak Chan Nikki P. Y. Lee Kwok Wah Chan Li Yan Xu En Min Li Sai Wah Tsao Qing-Yu He Annie L. M. Cheung Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression Nature Communications
author_facet	Wen Wen Xu Bin Li Xin Yuan Guan Sookja K. Chung Yang Wang Yim Ling Yip Simon Y. K. Law Kin Tak Chan Nikki P. Y. Lee Kwok Wah Chan Li Yan Xu En Min Li Sai Wah Tsao Qing-Yu He Annie L. M. Cheung
author_sort	Wen Wen Xu
title	Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
title_short	Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
title_full	Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
title_fullStr	Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
title_full_unstemmed	Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
title_sort	cancer cell-secreted igf2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-02-01
description	Cancer cells can affect cancer progression by producing systemic effects. Here, the authors show that IGF2 produced by oesophageal cancer cells increases secretion of VEGF from cancer-associated fibroblasts resulting in systemic mobilization of bone marrow-derived cells and increased metastases.
url	https://doi.org/10.1038/ncomms14399
work_keys_str_mv	AT wenwenxu cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT binli cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT xinyuanguan cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT sookjakchung cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT yangwang cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT yimlingyip cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT simonyklaw cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT kintakchan cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT nikkipylee cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT kwokwahchan cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT liyanxu cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT enminli cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT saiwahtsao cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT qingyuhe cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression AT annielmcheung cancercellsecretedigf2instigatesfibroblastsandbonemarrowderivedvascularprogenitorcellstopromotecancerprogression
_version_	1721451749205606400

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression

Similar Items