Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like
Stereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both motors to regulate stereocilia length.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10833 |
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doaj-42f55193d572437c9f31dff7d28365952021-05-11T10:56:19ZengNature Publishing GroupNature Communications2041-17232016-03-017111710.1038/ncomms10833Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-likeSeham Ebrahim0Matthew R. Avenarius1M’hamed Grati2Jocelyn F. Krey3Alanna M. Windsor4Aurea D. Sousa5Angela Ballesteros6Runjia Cui7Bryan A. Millis8Felipe T. Salles9Michelle A. Baird10Michael W. Davidson11Sherri M. Jones12Dongseok Choi13Lijin Dong14Manmeet H. Raval15Christopher M. Yengo16Peter G. Barr-Gillespie17Bechara Kachar18Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthOregon Hearing Research Center and Vollum Institute, Oregon Health & Science UniversityLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthOregon Hearing Research Center and Vollum Institute, Oregon Health & Science UniversityLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthNational High Magnetic Field Laboratory and Department of Biological Science, Florida State UniversityNational High Magnetic Field Laboratory and Department of Biological Science, Florida State UniversityDepartment of Special Education and Communication Disorders, University of Nebraska-LincolnDepartment of Public Health and Preventive Medicine, Oregon Health and Science UniversityGenetic Engineering Core, National Eye Institute, National Institutes of HealthDepartment of Cellular and Molecular Physiology, Penn State University College of MedicineDepartment of Cellular and Molecular Physiology, Penn State University College of MedicineOregon Hearing Research Center and Vollum Institute, Oregon Health & Science UniversityLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthStereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both motors to regulate stereocilia length.https://doi.org/10.1038/ncomms10833 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Seham Ebrahim Matthew R. Avenarius M’hamed Grati Jocelyn F. Krey Alanna M. Windsor Aurea D. Sousa Angela Ballesteros Runjia Cui Bryan A. Millis Felipe T. Salles Michelle A. Baird Michael W. Davidson Sherri M. Jones Dongseok Choi Lijin Dong Manmeet H. Raval Christopher M. Yengo Peter G. Barr-Gillespie Bechara Kachar |
| spellingShingle |
Seham Ebrahim Matthew R. Avenarius M’hamed Grati Jocelyn F. Krey Alanna M. Windsor Aurea D. Sousa Angela Ballesteros Runjia Cui Bryan A. Millis Felipe T. Salles Michelle A. Baird Michael W. Davidson Sherri M. Jones Dongseok Choi Lijin Dong Manmeet H. Raval Christopher M. Yengo Peter G. Barr-Gillespie Bechara Kachar Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like Nature Communications |
| author_facet |
Seham Ebrahim Matthew R. Avenarius M’hamed Grati Jocelyn F. Krey Alanna M. Windsor Aurea D. Sousa Angela Ballesteros Runjia Cui Bryan A. Millis Felipe T. Salles Michelle A. Baird Michael W. Davidson Sherri M. Jones Dongseok Choi Lijin Dong Manmeet H. Raval Christopher M. Yengo Peter G. Barr-Gillespie Bechara Kachar |
| author_sort |
Seham Ebrahim |
| title |
Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like |
| title_short |
Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like |
| title_full |
Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like |
| title_fullStr |
Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like |
| title_full_unstemmed |
Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like |
| title_sort |
stereocilia-staircase spacing is influenced by myosin iii motors and their cargos espin-1 and espin-like |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-03-01 |
| description |
Stereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both motors to regulate stereocilia length. |
| url |
https://doi.org/10.1038/ncomms10833 |
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