Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses
Chronic stress can impair the health of human brains. An important strategy that may prevent the accumulation of stress may be the consumption of functional foods. When senescence-accelerated mice prone 10 (SAMP10), a stress-sensitive strain, were loaded with stress using imposed male mouse territor...
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doaj-42f9fdbc45374c589cea5f72dd79b9952020-11-25T01:35:49ZengMDPI AGNutrients2072-66432020-01-0112117410.3390/nu12010174nu12010174Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress ResponsesKeiko Unno0Akira Sumiyoshi1Tomokazu Konishi2Michiko Hayashi3Kyoko Taguchi4Yoshio Muguruma5Koichi Inoue6Kazuaki Iguchi7Hiroi Nonaka8Ryuta Kawashima9Sanae Hasegawa-Ishii10Atsuyoshi Shimada11Yoriyuki Nakamura12Tea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanInstitute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanFaculty of Bioresource Sciences, Akita Prefectural University, Shimoshinjo Nakano, Akita 010-0195, JapanTea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanTea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, JapanCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, JapanSchool of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanInstitute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanInstitute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanFaculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka, Tokyo 181-8612, JapanFaculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka, Tokyo 181-8612, JapanTea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanChronic stress can impair the health of human brains. An important strategy that may prevent the accumulation of stress may be the consumption of functional foods. When senescence-accelerated mice prone 10 (SAMP10), a stress-sensitive strain, were loaded with stress using imposed male mouse territoriality, brain volume decreased. However, in mice that ingested theanine (6 mg/kg), the main amino acid in tea leaves, brain atrophy was suppressed, even under stress. On the other hand, brain atrophy was not clearly observed in a mouse strain that aged normally (Slc:ddY). The expression level of the transcription factor <i>Npas4</i> (neuronal PAS domain protein 4), which regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity, decreased in the hippocampus and prefrontal cortex of stressed SAMP10 mice, but increased in mice that ingested theanine. Lipocalin 2 (<i>Lcn2)</i>, the expression of which increased in response to stress, was significantly high in the hippocampus and prefrontal cortex of stressed SAMP10 mice, but not in mice that ingested theanine. These data suggest that <i>Npas4</i> and <i>Lcn2</i> are involved in the brain atrophy and stress vulnerability of SAMP10 mice, which are prevented by the consumption of theanine, causing changes in the expression of these genes.https://www.mdpi.com/2072-6643/12/1/174brain atrophychronic stresshippocampusmri analysisprefrontal cortextheaninesamp10 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keiko Unno Akira Sumiyoshi Tomokazu Konishi Michiko Hayashi Kyoko Taguchi Yoshio Muguruma Koichi Inoue Kazuaki Iguchi Hiroi Nonaka Ryuta Kawashima Sanae Hasegawa-Ishii Atsuyoshi Shimada Yoriyuki Nakamura |
spellingShingle |
Keiko Unno Akira Sumiyoshi Tomokazu Konishi Michiko Hayashi Kyoko Taguchi Yoshio Muguruma Koichi Inoue Kazuaki Iguchi Hiroi Nonaka Ryuta Kawashima Sanae Hasegawa-Ishii Atsuyoshi Shimada Yoriyuki Nakamura Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses Nutrients brain atrophy chronic stress hippocampus mri analysis prefrontal cortex theanine samp10 |
author_facet |
Keiko Unno Akira Sumiyoshi Tomokazu Konishi Michiko Hayashi Kyoko Taguchi Yoshio Muguruma Koichi Inoue Kazuaki Iguchi Hiroi Nonaka Ryuta Kawashima Sanae Hasegawa-Ishii Atsuyoshi Shimada Yoriyuki Nakamura |
author_sort |
Keiko Unno |
title |
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses |
title_short |
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses |
title_full |
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses |
title_fullStr |
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses |
title_full_unstemmed |
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses |
title_sort |
theanine, the main amino acid in tea, prevents stress-induced brain atrophy by modifying early stress responses |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-01-01 |
description |
Chronic stress can impair the health of human brains. An important strategy that may prevent the accumulation of stress may be the consumption of functional foods. When senescence-accelerated mice prone 10 (SAMP10), a stress-sensitive strain, were loaded with stress using imposed male mouse territoriality, brain volume decreased. However, in mice that ingested theanine (6 mg/kg), the main amino acid in tea leaves, brain atrophy was suppressed, even under stress. On the other hand, brain atrophy was not clearly observed in a mouse strain that aged normally (Slc:ddY). The expression level of the transcription factor <i>Npas4</i> (neuronal PAS domain protein 4), which regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity, decreased in the hippocampus and prefrontal cortex of stressed SAMP10 mice, but increased in mice that ingested theanine. Lipocalin 2 (<i>Lcn2)</i>, the expression of which increased in response to stress, was significantly high in the hippocampus and prefrontal cortex of stressed SAMP10 mice, but not in mice that ingested theanine. These data suggest that <i>Npas4</i> and <i>Lcn2</i> are involved in the brain atrophy and stress vulnerability of SAMP10 mice, which are prevented by the consumption of theanine, causing changes in the expression of these genes. |
topic |
brain atrophy chronic stress hippocampus mri analysis prefrontal cortex theanine samp10 |
url |
https://www.mdpi.com/2072-6643/12/1/174 |
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