Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease
The interplay between peripheral and central inflammation has a significant role in dopaminergic neural death in nigrostriatal pathway, although no direct assessment of inflammation has been performed in relation to dopaminergic neuronal loss in striatal nuclei. In this study, the correlation of neu...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-04-01
|
Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00234/full |
id |
doaj-42fff2a6403a4e1f97dc1e06895e3a28 |
---|---|
record_format |
Article |
spelling |
doaj-42fff2a6403a4e1f97dc1e06895e3a282020-11-24T22:24:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-04-01910.3389/fneur.2018.00234324826Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson DiseaseHossein Sanjari MoghaddamFarzaneh Ghazi SherbafMahtab Mojtahed ZadehAmir Ashraf-GanjoueiMohammad Hadi AarabiThe interplay between peripheral and central inflammation has a significant role in dopaminergic neural death in nigrostriatal pathway, although no direct assessment of inflammation has been performed in relation to dopaminergic neuronal loss in striatal nuclei. In this study, the correlation of neutrophil to lymphocyte ratio (NLR) as a marker of peripheral inflammation to striatal binding ratios (SBRs) of DAT SPECT images in bilateral caudate and putamen nuclei was calculated in 388 drug-naïve early PD patients [288 tremor dominant (TD), 73 postural instability and gait difficulty (PIGD), and 27 indeterminate] and 148 controls. NLR was significantly higher in PD patients than in age- and sex-matched healthy controls, and showed a negative correlation to SBR in bilateral putamen and ipsilateral caudate in all PD subjects. Among our three subgroups, only TD patients showed remarkable results. A positive association between NLR and motor severity was observed in TD subgroup. Besides, NLR could negatively predict the SBR in ipsilateral and contralateral putamen and caudate nuclei in tremulous phenotype. Nonetheless, we found no significant association between NLR and other clinical and imaging findings in PIGD and indeterminate subgroups, supporting the presence of distinct underlying pathologic mechanisms between tremor and non-tremor predominant PD at early stages of the disease.http://journal.frontiersin.org/article/10.3389/fneur.2018.00234/fullParkinson diseaseDATScan dataperipheral inflammationmotor subtypespostural instability and gait difficultytremor-dominant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hossein Sanjari Moghaddam Farzaneh Ghazi Sherbaf Mahtab Mojtahed Zadeh Amir Ashraf-Ganjouei Mohammad Hadi Aarabi |
spellingShingle |
Hossein Sanjari Moghaddam Farzaneh Ghazi Sherbaf Mahtab Mojtahed Zadeh Amir Ashraf-Ganjouei Mohammad Hadi Aarabi Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease Frontiers in Neurology Parkinson disease DATScan data peripheral inflammation motor subtypes postural instability and gait difficulty tremor-dominant |
author_facet |
Hossein Sanjari Moghaddam Farzaneh Ghazi Sherbaf Mahtab Mojtahed Zadeh Amir Ashraf-Ganjouei Mohammad Hadi Aarabi |
author_sort |
Hossein Sanjari Moghaddam |
title |
Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease |
title_short |
Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease |
title_full |
Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease |
title_fullStr |
Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease |
title_full_unstemmed |
Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease |
title_sort |
association between peripheral inflammation and datscan data of the striatal nuclei in different motor subtypes of parkinson disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-04-01 |
description |
The interplay between peripheral and central inflammation has a significant role in dopaminergic neural death in nigrostriatal pathway, although no direct assessment of inflammation has been performed in relation to dopaminergic neuronal loss in striatal nuclei. In this study, the correlation of neutrophil to lymphocyte ratio (NLR) as a marker of peripheral inflammation to striatal binding ratios (SBRs) of DAT SPECT images in bilateral caudate and putamen nuclei was calculated in 388 drug-naïve early PD patients [288 tremor dominant (TD), 73 postural instability and gait difficulty (PIGD), and 27 indeterminate] and 148 controls. NLR was significantly higher in PD patients than in age- and sex-matched healthy controls, and showed a negative correlation to SBR in bilateral putamen and ipsilateral caudate in all PD subjects. Among our three subgroups, only TD patients showed remarkable results. A positive association between NLR and motor severity was observed in TD subgroup. Besides, NLR could negatively predict the SBR in ipsilateral and contralateral putamen and caudate nuclei in tremulous phenotype. Nonetheless, we found no significant association between NLR and other clinical and imaging findings in PIGD and indeterminate subgroups, supporting the presence of distinct underlying pathologic mechanisms between tremor and non-tremor predominant PD at early stages of the disease. |
topic |
Parkinson disease DATScan data peripheral inflammation motor subtypes postural instability and gait difficulty tremor-dominant |
url |
http://journal.frontiersin.org/article/10.3389/fneur.2018.00234/full |
work_keys_str_mv |
AT hosseinsanjarimoghaddam associationbetweenperipheralinflammationanddatscandataofthestriatalnucleiindifferentmotorsubtypesofparkinsondisease AT farzanehghazisherbaf associationbetweenperipheralinflammationanddatscandataofthestriatalnucleiindifferentmotorsubtypesofparkinsondisease AT mahtabmojtahedzadeh associationbetweenperipheralinflammationanddatscandataofthestriatalnucleiindifferentmotorsubtypesofparkinsondisease AT amirashrafganjouei associationbetweenperipheralinflammationanddatscandataofthestriatalnucleiindifferentmotorsubtypesofparkinsondisease AT mohammadhadiaarabi associationbetweenperipheralinflammationanddatscandataofthestriatalnucleiindifferentmotorsubtypesofparkinsondisease |
_version_ |
1725760453423923200 |