Correlation of sST2 and Fascin contents in malignant pleural effusion with malignant proliferation and invasion of cancer cells

• Main Author: Dong Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-03-01
• Series: Journal of Hainan Medical University
• Subjects: Malignant pleural effusion; Soluble ST2 protein; Fascin; Proliferation; Invasion
• Online Access: http://www.hnykdxxb.com/PDF/201803/22.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the correlation of sST2 and Fascin contents in malignant pleural effusion with malignant proliferation and invasion of cancer cells. Methods: Lung cancer patients with malignant pleural effusion who were treated in the Fourth (Xingyuan) Hospital of Yulin between November 2014 and November 2016 were retrospectively analyzed and selected as the malignant group of the research, and patients with heart failure, hypoalbuminemia and pleural effusion during the same period were selected as the control group. The pleural effusion was collected from the two groups of patients to determine the contents of sST2 and Fascin, and the lung cancer lesions and adjacent lesions were collected from the malignant group to determine the mRNA expression of the cell proliferation genes and invasion genes. Results: sST2 and Fascin contents in pleural effusion of malignant group were significantly higher than those of control group; KI-67, BCL2, N-cadherin and MMP9 mRNA expression in lung cancer lesions were significantly higher than those in adjacent lesions whereas MTS1, LKB1, Bin-1, TMSG-1 and E-cadherin mRNA expression were significantly lower than those in adjacent lesions; KI-67 and BCL2 mRNA expression in lung cancer lesions with high sST2 content were significantly higher than those in lung cancer lesions with low sST2 content whereas MTS1 and LKB1 mRNA expression were significantly lower than those in lung cancer lesions with low sST2 content; Bin-1, TMSG-1 and E-cadherin mRNA expression in lung cancer lesions with high Fascin content were significantly lower than those in lung cancer lesions with low Fascin content whereas N-cadherin and MMP9 mRNA expression were significantly higher than those in lung cancer lesions with low Fascin content. Conclusions: The increase of sST and Fascin in malignant pleural effusion are related to the aggravation of cancer cell proliferation and invasion respectively.