Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP amyloid formation and link their properties to...

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Bibliographic Details
Main Authors: Andisheh Abedini, Annette Plesner, Ping Cao, Zachary Ridgway, Jinghua Zhang, Ling-Hsien Tu, Chris T Middleton, Brian Chao, Daniel J Sartori, Fanling Meng, Hui Wang, Amy G Wong, Martin T Zanni, C Bruce Verchere, Daniel P Raleigh, Ann Marie Schmidt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
amylin
IAPP
oligomer
diabetes
amyloid
islet amyloid polypeptide
Online Access:https://elifesciences.org/articles/12977

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