A Novel Small Molecule Which Increases Osteoprotegerin Expression and Protects Against Ovariectomy-Related Bone Loss in Rats

A Novel Small Molecule Which Increases Osteoprotegerin Expression and Protects Against Ovariectomy-Related Bone Loss in Rats

The ratio of osteoprotegerin (OPG) to the receptor activator of NF-κB ligand (RANKL) is a key determinant in the regulation of bone metabolism. The study was performed to screen novel anti-osteoporotic drugs regulating OPG/RANKL ratio and evaluate their effect on bone metabolism. According to the sc...

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Bibliographic Details
Main Authors: Xiaowan Han, Shiqiang Gong, Ni Li, Xiao Wang, Peng Liu, Yanni Xu, Xiaobo He, Wei Jiang, Shuyi Si
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
osteoprotegerin
receptor activator of NF-κB ligand
osteoblast
osteoclast
osteoporosis
Wnt/β-catenin signaling
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00103/full

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