Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer
Abstracts: Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer (DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection, change of inflamm...
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doaj-432d7219553c48f59f3919d5de5eb0392020-11-24T22:00:44ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762019-03-01142130143Electrospun nanofibers as a wound dressing for treating diabetic foot ulcerYan Liu0Shiya Zhou1Yanlin Gao2Yinglei Zhai3Shenyang Pharmaceutical University, No.103, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaSchool of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding author. Department of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenyang 110016, China. Tel.: +86 24 43520357.Abstracts: Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer (DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection, change of inflammatory responses, lack of extracellular matrix (ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient (API) or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing (ND) that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU. Keywords: Nanofibers, Nanofibrous dressing, Diabetic foot ulcer, Uniaxial electrospinning, Coaxial electrospinninghttp://www.sciencedirect.com/science/article/pii/S1818087618301065 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai |
spellingShingle |
Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer Asian Journal of Pharmaceutical Sciences |
author_facet |
Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai |
author_sort |
Yan Liu |
title |
Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer |
title_short |
Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer |
title_full |
Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer |
title_fullStr |
Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer |
title_full_unstemmed |
Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer |
title_sort |
electrospun nanofibers as a wound dressing for treating diabetic foot ulcer |
publisher |
Elsevier |
series |
Asian Journal of Pharmaceutical Sciences |
issn |
1818-0876 |
publishDate |
2019-03-01 |
description |
Abstracts: Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer (DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection, change of inflammatory responses, lack of extracellular matrix (ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient (API) or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing (ND) that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU. Keywords: Nanofibers, Nanofibrous dressing, Diabetic foot ulcer, Uniaxial electrospinning, Coaxial electrospinning |
url |
http://www.sciencedirect.com/science/article/pii/S1818087618301065 |
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