Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial Surgery
The purpose of this study was to evaluate the mechanical strength and biodegradation of a ZK60 plate coated with poly(l-lactic)-acid polymer (PLLA) in a LeFort I osteotomy canine model for maxillofacial applications. The PLLA-coated ZK60 plate and screw were evaluated using a LeFort I osteotomy cani...
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doaj-433b5c5187a74acdae1477b84267cd922020-11-25T03:03:51ZengMDPI AGMetals2075-47012020-05-011072472410.3390/met10060724Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial SurgerySoo-Hwan Byun0Ho-Kyung Lim1Sung-Mi Lee2Hyoun-Ee Kim3Soung-Min Kim4Jong-Ho Lee5Department of Oral & Maxillofacial Surgery, Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, KoreaBiomedical Implant Convergence Research Center, Advanced Institutes of Convergence Technology, Suwon 16229, KoreaBiomedical Implant Convergence Research Center, Advanced Institutes of Convergence Technology, Suwon 16229, KoreaDepartment of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, KoreaDepartment of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, KoreaThe purpose of this study was to evaluate the mechanical strength and biodegradation of a ZK60 plate coated with poly(l-lactic)-acid polymer (PLLA) in a LeFort I osteotomy canine model for maxillofacial applications. The PLLA-coated ZK60 plate and screw were evaluated using a LeFort I osteotomy canine model based on five beagles. The presence of wound dehiscence, plate exposure, gas formation, inflammation, pus formation, occlusion, food intake, and fistula formation were evaluated. After 12 weeks, these dogs were sacrificed, and an X-ray micro-computed tomography (µCT) was conducted. Plate exposure, gas formation, and external fistula were not observed, and the occlusion remained stable. Wound dehiscence did not heal for 12 weeks. CT images did not show plates in all the five dogs. A few screw bodies fixed in the bone remained, and screw heads were completely absorbed after 12 weeks. These findings may be attributed to the inability to optimize the absorption rate with PLLA coating. Rapid biodegradation of the PLLA-coated ZK60 occurred due to the formation of microcracks during the bending process. Further improvement to the plate system with PLLA-coated ZK60 is required using other surface coating methods or alternative Mg alloys.https://www.mdpi.com/2075-4701/10/6/724biodegradableplate and screwmagnesiumalloyZK60PLLA coating |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soo-Hwan Byun Ho-Kyung Lim Sung-Mi Lee Hyoun-Ee Kim Soung-Min Kim Jong-Ho Lee |
spellingShingle |
Soo-Hwan Byun Ho-Kyung Lim Sung-Mi Lee Hyoun-Ee Kim Soung-Min Kim Jong-Ho Lee Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial Surgery Metals biodegradable plate and screw magnesium alloy ZK60 PLLA coating |
author_facet |
Soo-Hwan Byun Ho-Kyung Lim Sung-Mi Lee Hyoun-Ee Kim Soung-Min Kim Jong-Ho Lee |
author_sort |
Soo-Hwan Byun |
title |
Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial Surgery |
title_short |
Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial Surgery |
title_full |
Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial Surgery |
title_fullStr |
Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial Surgery |
title_full_unstemmed |
Biodegradable Magnesium Alloy (ZK60) with a Poly(l-lactic)-Acid Polymer Coating for Maxillofacial Surgery |
title_sort |
biodegradable magnesium alloy (zk60) with a poly(l-lactic)-acid polymer coating for maxillofacial surgery |
publisher |
MDPI AG |
series |
Metals |
issn |
2075-4701 |
publishDate |
2020-05-01 |
description |
The purpose of this study was to evaluate the mechanical strength and biodegradation of a ZK60 plate coated with poly(l-lactic)-acid polymer (PLLA) in a LeFort I osteotomy canine model for maxillofacial applications. The PLLA-coated ZK60 plate and screw were evaluated using a LeFort I osteotomy canine model based on five beagles. The presence of wound dehiscence, plate exposure, gas formation, inflammation, pus formation, occlusion, food intake, and fistula formation were evaluated. After 12 weeks, these dogs were sacrificed, and an X-ray micro-computed tomography (µCT) was conducted. Plate exposure, gas formation, and external fistula were not observed, and the occlusion remained stable. Wound dehiscence did not heal for 12 weeks. CT images did not show plates in all the five dogs. A few screw bodies fixed in the bone remained, and screw heads were completely absorbed after 12 weeks. These findings may be attributed to the inability to optimize the absorption rate with PLLA coating. Rapid biodegradation of the PLLA-coated ZK60 occurred due to the formation of microcracks during the bending process. Further improvement to the plate system with PLLA-coated ZK60 is required using other surface coating methods or alternative Mg alloys. |
topic |
biodegradable plate and screw magnesium alloy ZK60 PLLA coating |
url |
https://www.mdpi.com/2075-4701/10/6/724 |
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