Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

Background & Aims: Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylation to fructose-1-phosphate via the ketohexo...

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Bibliographic Details
Main Authors: Emma L. Shepherd, Raquel Saborano, Ellie Northall, Kae Matsuda, Hitomi Ogino, Hiroaki Yashiro, Jason Pickens, Ryan E. Feaver, Banumathi K. Cole, Stephen A. Hoang, Mark J. Lawson, Matthew Olson, Robert A. Figler, John E. Reardon, Nobuhiro Nishigaki, Brian R. Wamhoff, Ulrich L. Günther, Gideon Hirschfield, Derek M. Erion, Patricia F. Lalor
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:JHEP Reports
Subjects:
NAFLD
Metabolism
Fructose
Fibrosis
Treatment
NASH
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555920301518

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