Tyrosine Phosphorylation Modulates Peroxiredoxin-2 Activity in Normal and Diseased Red Cells

Tyrosine Phosphorylation Modulates Peroxiredoxin-2 Activity in Normal and Diseased Red Cells

Peroxiredoxin-2 (Prx2) is the third most abundant cytoplasmic protein in red blood cells. Prx2 belongs to a well-known family of antioxidants, the peroxiredoxins (Prxs), that are widely expressed in mammalian cells. Prx2 is a typical, homodimeric, 2-Cys Prx that uses two cysteine residues to accompl...

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Bibliographic Details
Main Authors: Alessandro Mattè, Enrica Federti, Elena Tibaldi, Maria Luisa Di Paolo, Giovanni Bisello, Mariarita Bertoldi, Andrea Carpentieri, Pietro Pucci, Iana Iatchencko, Anand B. Wilson, Veronica Riccardi, Angela Siciliano, Francesco Turrini, Dae Won Kim, Soo Young Choi, Anna Maria Brunati, Lucia De Franceschi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antioxidants
Subjects:
peroxiredoxin-2
tyrosine phosphorylation
Syk
sickle cell disease
oxidation
Online Access:https://www.mdpi.com/2076-3921/10/2/206

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