Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey
Background: The containment measures taken by Italian government authorities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the interruption of neurological activities of outpatient clinics. Vulnerable patients, as Parkinson's disease (PD) and dystonic p...
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Frontiers Media S.A.
2020-12-01
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Series: | Frontiers in Neurology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.616550/full |
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language |
English |
format |
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DOAJ |
author |
Carla Piano Francesco Bove Francesco Bove Tommaso Tufo Isabella Imbimbo Isabella Imbimbo Danilo Genovese Danilo Genovese Alessandro Stefani Massimo Marano Antonella Peppe Livia Brusa Rocco Cerroni Francesco Motolese Enrico Di Stasio Enrico Di Stasio Marianna Mazza Antonio Daniele Antonio Daniele Alessandro Olivi Alessandro Olivi Paolo Calabresi Paolo Calabresi Anna Rita Bentivoglio Anna Rita Bentivoglio Lazio DBS Study Group |
spellingShingle |
Carla Piano Francesco Bove Francesco Bove Tommaso Tufo Isabella Imbimbo Isabella Imbimbo Danilo Genovese Danilo Genovese Alessandro Stefani Massimo Marano Antonella Peppe Livia Brusa Rocco Cerroni Francesco Motolese Enrico Di Stasio Enrico Di Stasio Marianna Mazza Antonio Daniele Antonio Daniele Alessandro Olivi Alessandro Olivi Paolo Calabresi Paolo Calabresi Anna Rita Bentivoglio Anna Rita Bentivoglio Lazio DBS Study Group Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey Frontiers in Neurology COVID-19 SARS-CoV-2 deep brain stimulation Parkinson's disease dystonia |
author_facet |
Carla Piano Francesco Bove Francesco Bove Tommaso Tufo Isabella Imbimbo Isabella Imbimbo Danilo Genovese Danilo Genovese Alessandro Stefani Massimo Marano Antonella Peppe Livia Brusa Rocco Cerroni Francesco Motolese Enrico Di Stasio Enrico Di Stasio Marianna Mazza Antonio Daniele Antonio Daniele Alessandro Olivi Alessandro Olivi Paolo Calabresi Paolo Calabresi Anna Rita Bentivoglio Anna Rita Bentivoglio Lazio DBS Study Group |
author_sort |
Carla Piano |
title |
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey |
title_short |
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey |
title_full |
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey |
title_fullStr |
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey |
title_full_unstemmed |
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey |
title_sort |
effects of covid-19 lockdown on movement disorders patients with deep brain stimulation: a multicenter survey |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-12-01 |
description |
Background: The containment measures taken by Italian government authorities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the interruption of neurological activities of outpatient clinics. Vulnerable patients, as Parkinson's disease (PD) and dystonic patients with deep brain stimulation (DBS), may have an increased risk of chronic stress related to social restriction measures and may show a potential worsening of motor and psychiatric symptoms.Methods: This cross-sectional multicenter study was carried out during the SARS-CoV-2 pandemic and was based on a structured survey administered during a telephone call. The questionnaire was designed to gather motor and/or psychiatric effects of the lockdown and coronavirus disease 2019 (COVID-19) epidemiologic information in PD and dystonic patients with a functioning DBS implant.Results: One hundred four patients were included in the study, 90 affected by PD and 14 by dystonia. Forty-nine patients reported a subjective perception of worsening of global neurological symptoms (motor and/or psychiatric) related to the containment measures. In the multivariate analysis, having problems with the DBS device was the only independent predictor of motor worsening [odds ratio (OR) = 3.10 (1.22–7.91), p = 0.018]. Independent predictors of psychiatric worsening were instrumental activities of daily living (IADL) score [OR = 0.78 (0.64–0.95), p = 0.012] and problems with DBS [OR = 5.69 (1.95–16.62), p = 0.001]. Only one patient underwent nasopharyngeal swabs, both negative, and no patient received a diagnosis of COVID-19.Conclusions: Lockdown restriction measures were associated with subjective worsening of motor and psychiatric symptoms in PD and dystonic patients treated with DBS, and they may have exacerbated the burden of neurological disease and increased the chronic stress related to the DBS management. |
topic |
COVID-19 SARS-CoV-2 deep brain stimulation Parkinson's disease dystonia |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2020.616550/full |
work_keys_str_mv |
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doaj-434c6401e1df4879b87aebb584b1c2f02020-12-16T05:03:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-12-011110.3389/fneur.2020.616550616550Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter SurveyCarla Piano0Francesco Bove1Francesco Bove2Tommaso Tufo3Isabella Imbimbo4Isabella Imbimbo5Danilo Genovese6Danilo Genovese7Alessandro Stefani8Massimo Marano9Antonella Peppe10Livia Brusa11Rocco Cerroni12Francesco Motolese13Enrico Di Stasio14Enrico Di Stasio15Marianna Mazza16Antonio Daniele17Antonio Daniele18Alessandro Olivi19Alessandro Olivi20Paolo Calabresi21Paolo Calabresi22Anna Rita Bentivoglio23Anna Rita Bentivoglio24Lazio DBS Study GroupNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Neurosciences, Università Cattolica del Sacro Cuore, Rome, ItalyNeurosurgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyFondazione Don Carlo Gnocchi Onlus, Milan, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Neurosciences, Università Cattolica del Sacro Cuore, Rome, ItalyDepartment of System Medicine, Unità Operativa Semplice Dipartimentale (UOSD) Parkinson, University of Rome Tor Vergata, Rome, ItalyNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, ItalyIRCCS Santa Lucia Foundation, Rome, ItalyNeurology Unit, S. Eugenio Hospital, Rome, ItalyDepartment of System Medicine, Unità Operativa Semplice Dipartimentale (UOSD) Parkinson, University of Rome Tor Vergata, Rome, ItalyNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, ItalyUnit of Chemistry, Biochemistry and Clinical Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy0Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Rome, Italy1Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Neurosciences, Università Cattolica del Sacro Cuore, Rome, ItalyDepartment of Neurosciences, Università Cattolica del Sacro Cuore, Rome, ItalyNeurosurgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Neurosciences, Università Cattolica del Sacro Cuore, Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Neurosciences, Università Cattolica del Sacro Cuore, Rome, ItalyBackground: The containment measures taken by Italian government authorities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the interruption of neurological activities of outpatient clinics. Vulnerable patients, as Parkinson's disease (PD) and dystonic patients with deep brain stimulation (DBS), may have an increased risk of chronic stress related to social restriction measures and may show a potential worsening of motor and psychiatric symptoms.Methods: This cross-sectional multicenter study was carried out during the SARS-CoV-2 pandemic and was based on a structured survey administered during a telephone call. The questionnaire was designed to gather motor and/or psychiatric effects of the lockdown and coronavirus disease 2019 (COVID-19) epidemiologic information in PD and dystonic patients with a functioning DBS implant.Results: One hundred four patients were included in the study, 90 affected by PD and 14 by dystonia. Forty-nine patients reported a subjective perception of worsening of global neurological symptoms (motor and/or psychiatric) related to the containment measures. In the multivariate analysis, having problems with the DBS device was the only independent predictor of motor worsening [odds ratio (OR) = 3.10 (1.22–7.91), p = 0.018]. Independent predictors of psychiatric worsening were instrumental activities of daily living (IADL) score [OR = 0.78 (0.64–0.95), p = 0.012] and problems with DBS [OR = 5.69 (1.95–16.62), p = 0.001]. Only one patient underwent nasopharyngeal swabs, both negative, and no patient received a diagnosis of COVID-19.Conclusions: Lockdown restriction measures were associated with subjective worsening of motor and psychiatric symptoms in PD and dystonic patients treated with DBS, and they may have exacerbated the burden of neurological disease and increased the chronic stress related to the DBS management.https://www.frontiersin.org/articles/10.3389/fneur.2020.616550/fullCOVID-19SARS-CoV-2deep brain stimulationParkinson's diseasedystonia |