Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific
Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training.Objective: To...
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Frontiers Media S.A.
2020-08-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01605/full |
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English |
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Article |
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DOAJ |
author |
Daniel Leung Gilbert T. Chua Alric V. Mondragon Youjia Zhong Le Nguyen-Ngoc-Quynh Kohsuke Imai Pandiarajan Vignesh Narissara Suratannon Huawei Mao Wen-I Lee Yae-Jean Kim Godfrey C. F. Chan Woei Kang Liew Le Thi Minh Huong Hirokazu Kanegane Dina Muktiarti Xiaodong Zhao Fatima Johanna Santos-Ocampo Amir Hamzah Abdul Latiff Reinhard Seger Hans D. Ochs Surjit Singh Pamela P. Lee Yu Lung Lau |
spellingShingle |
Daniel Leung Gilbert T. Chua Alric V. Mondragon Youjia Zhong Le Nguyen-Ngoc-Quynh Kohsuke Imai Pandiarajan Vignesh Narissara Suratannon Huawei Mao Wen-I Lee Yae-Jean Kim Godfrey C. F. Chan Woei Kang Liew Le Thi Minh Huong Hirokazu Kanegane Dina Muktiarti Xiaodong Zhao Fatima Johanna Santos-Ocampo Amir Hamzah Abdul Latiff Reinhard Seger Hans D. Ochs Surjit Singh Pamela P. Lee Yu Lung Lau Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific Frontiers in Immunology primary immunodeficiencies resource needs health resources immunology standard of care specialty training |
author_facet |
Daniel Leung Gilbert T. Chua Alric V. Mondragon Youjia Zhong Le Nguyen-Ngoc-Quynh Kohsuke Imai Pandiarajan Vignesh Narissara Suratannon Huawei Mao Wen-I Lee Yae-Jean Kim Godfrey C. F. Chan Woei Kang Liew Le Thi Minh Huong Hirokazu Kanegane Dina Muktiarti Xiaodong Zhao Fatima Johanna Santos-Ocampo Amir Hamzah Abdul Latiff Reinhard Seger Hans D. Ochs Surjit Singh Pamela P. Lee Yu Lung Lau |
author_sort |
Daniel Leung |
title |
Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific |
title_short |
Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific |
title_full |
Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific |
title_fullStr |
Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific |
title_full_unstemmed |
Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific |
title_sort |
current perspectives and unmet needs of primary immunodeficiency care in asia pacific |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-08-01 |
description |
Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training.Objective: To identify differences in PID patient care resource and training needs across Asia Pacific and propose a corresponding action plan.Methods: The Human Development Index (HDI) indicates the degree of socio-economic development in each country/region. Information related to investigations and learning issues were extracted from the abstracts and personal statements from all Schools and mapped onto resource and training needs. Correlations between HDI and country/region-specific parameters were tested by two-tailed Pearson correlation.Results: A total of 427 abstracts were received in nine Schools between 2015 and 2020, predominantly on immunodeficiencies affecting cellular and humoral immunity. Genetic confirmation was described in 61.8% of abstracts, and its absence negatively correlated with HDI (r = −0.696, p = 0.004). Essential immunologic and genetic tests were not available in 25.4 and 29.5% of abstracts, respectively, and their absence negatively correlated with HDI (r = −0.788, p < 0.001; r = −0.739, p = 0.002). HDI positively correlated with average testing level (r = 0.742, p = 0.002). Cases from medium-HDI countries/regions focused on learning how to investigate a patient for PIDs in cases of severe or atypical infections, whereas those from very-high-HDI countries/regions, from which most faculty members originated, listed hematopoietic stem cell transplantation and gene therapy, newborn screening, and research as learning issues more frequently.Conclusion: There are unique HDI-related PID resource and training needs in each country/region. APSID proposes HDI group-specific strategies to improve PID care and education in her member countries/regions. Further quantitative analysis of needs in PID care in Asia Pacific is needed for lobbying governments to increase their support for PID care and research. |
topic |
primary immunodeficiencies resource needs health resources immunology standard of care specialty training |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.01605/full |
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doaj-4352d0a6084d4b8b8b3024b66756e1772020-11-25T03:52:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01605551663Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia PacificDaniel Leung0Gilbert T. Chua1Alric V. Mondragon2Youjia Zhong3Le Nguyen-Ngoc-Quynh4Kohsuke Imai5Pandiarajan Vignesh6Narissara Suratannon7Huawei Mao8Wen-I Lee9Yae-Jean Kim10Godfrey C. F. Chan11Woei Kang Liew12Le Thi Minh Huong13Hirokazu Kanegane14Dina Muktiarti15Xiaodong Zhao16Fatima Johanna Santos-Ocampo17Amir Hamzah Abdul Latiff18Reinhard Seger19Hans D. Ochs20Surjit Singh21Pamela P. Lee22Yu Lung Lau23Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Medicine, University of the Philippines—Philippine General Hospital, Manila, PhilippinesKhoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, SingaporeNational Hospital of Pediatrics, Hanoi, VietnamDepartment of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaPediatric Allergy and Clinical Immunology Research Unit, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, ThailandChildren's Hospital of Chongqing Medical University, Chongqing, ChinaPrimary Immunodeficiency Care and Research (PICAR) Institute, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan0Department of Pediatrics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South KoreaDepartment of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China1Rheumatology and Immunology Service, Department of Pediatric Medicine, KK Women's and Children's Hospital, Singapore, SingaporeNational Hospital of Pediatrics, Hanoi, Vietnam2Department of Child Health and Development, Tokyo Medical and Dental University, Tokyo, Japan3Department of Child Health, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaChildren's Hospital of Chongqing Medical University, Chongqing, China4Section of Allergy/Immunology, Department of Pediatrics, Makati Medical Center, Makati City, Philippines5Allergy & Immunology Centre, Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia6Division of Immunology/HSCT, University Children's Hospital Zürich, Zürich, Switzerland7Department of Pediatrics, Seattle Children's Research Institute, University of Washington, Seattle, WA, United StatesDepartment of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaBackground: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training.Objective: To identify differences in PID patient care resource and training needs across Asia Pacific and propose a corresponding action plan.Methods: The Human Development Index (HDI) indicates the degree of socio-economic development in each country/region. Information related to investigations and learning issues were extracted from the abstracts and personal statements from all Schools and mapped onto resource and training needs. Correlations between HDI and country/region-specific parameters were tested by two-tailed Pearson correlation.Results: A total of 427 abstracts were received in nine Schools between 2015 and 2020, predominantly on immunodeficiencies affecting cellular and humoral immunity. Genetic confirmation was described in 61.8% of abstracts, and its absence negatively correlated with HDI (r = −0.696, p = 0.004). Essential immunologic and genetic tests were not available in 25.4 and 29.5% of abstracts, respectively, and their absence negatively correlated with HDI (r = −0.788, p < 0.001; r = −0.739, p = 0.002). HDI positively correlated with average testing level (r = 0.742, p = 0.002). Cases from medium-HDI countries/regions focused on learning how to investigate a patient for PIDs in cases of severe or atypical infections, whereas those from very-high-HDI countries/regions, from which most faculty members originated, listed hematopoietic stem cell transplantation and gene therapy, newborn screening, and research as learning issues more frequently.Conclusion: There are unique HDI-related PID resource and training needs in each country/region. APSID proposes HDI group-specific strategies to improve PID care and education in her member countries/regions. Further quantitative analysis of needs in PID care in Asia Pacific is needed for lobbying governments to increase their support for PID care and research.https://www.frontiersin.org/article/10.3389/fimmu.2020.01605/fullprimary immunodeficienciesresource needshealth resourcesimmunologystandard of carespecialty training |