Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes
UTP causes interleukin (IL)-6 production via mRNA expression through P2Y2/P2Y4 receptors in human HaCaT keratinocytes. In the present study, we analyzed the mechanism of UTP-induced IL-6 production in these cells. UTP, an agonist of P2Y2/P2Y4 receptors, induced phosphorylation of extracellular signa...
Main Authors: | Daisaku Kobayashi, Satoko Ohkubo, Norimichi Nakahata |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2006-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S134786131934349X |
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