Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A

Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A

The long QT syndrome type 3 (LQT3) is currently the 3rd most prevalent of the 15 known types of LQT syndrome. Cardiac events in LQT3 are less frequent than LQT1 and LQT2, but more likely to be fatal. LQT3 is caused by mutation in gene SCN5A, which codes for the Nav1.5 Na+ channel. Herein, we have ge...

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Main Authors: Xiaofei Yang, Fujian Wu, Jiaqi Zhong, Furong Li
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121000404
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spelling doaj-4360287383c04267a3b5d8486dc9bec62021-03-13T04:22:19ZengElsevierStem Cell Research1873-50612021-03-0151102194Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5AXiaofei Yang0Fujian Wu1Jiaqi Zhong2Furong Li3Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, 518020 Shenzhen, China; Guangdong Engineering Technology Research Center of Stem Cell and Cell Therapy, 518020 Shenzhen, China; Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation, 518020 Shenzhen, ChinaTranslational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, 518020 Shenzhen, China; Post-doctoral Scientific Research Station of Basic Medicine, Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Stem Cell and Cell Therapy, 518020 Shenzhen, China; Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation, 518020 Shenzhen, ChinaTranslational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, 518020 Shenzhen, China; Guangdong Engineering Technology Research Center of Stem Cell and Cell Therapy, 518020 Shenzhen, China; Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation, 518020 Shenzhen, ChinaTranslational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, 518020 Shenzhen, China; Post-doctoral Scientific Research Station of Basic Medicine, Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Stem Cell and Cell Therapy, 518020 Shenzhen, China; Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation, 518020 Shenzhen, China; Corresponding author at: 1017 Dongmen North Road, 518020 Shenzhen, China.The long QT syndrome type 3 (LQT3) is currently the 3rd most prevalent of the 15 known types of LQT syndrome. Cardiac events in LQT3 are less frequent than LQT1 and LQT2, but more likely to be fatal. LQT3 is caused by mutation in gene SCN5A, which codes for the Nav1.5 Na+ channel. Herein, we have generated a human embryonic stem cell line (WAe009-A-48) carrying a LQTS related mutation in SCN5A (WAe009-A-48). The WAe009-A-48 line maintained stem cell like morphology, pluripotency, normal karyotype and could differentiate into all three germ layers in vivo.http://www.sciencedirect.com/science/article/pii/S1873506121000404
collection DOAJ
language English
format Article
sources DOAJ
author Xiaofei Yang
Fujian Wu
Jiaqi Zhong
Furong Li
spellingShingle Xiaofei Yang
Fujian Wu
Jiaqi Zhong
Furong Li
Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A
Stem Cell Research
author_facet Xiaofei Yang
Fujian Wu
Jiaqi Zhong
Furong Li
author_sort Xiaofei Yang
title Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A
title_short Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A
title_full Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A
title_fullStr Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A
title_full_unstemmed Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A
title_sort establishment of human embryonic stem cell wae009-a-48 carrying a long qt syndrome mutation in scn5a
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2021-03-01
description The long QT syndrome type 3 (LQT3) is currently the 3rd most prevalent of the 15 known types of LQT syndrome. Cardiac events in LQT3 are less frequent than LQT1 and LQT2, but more likely to be fatal. LQT3 is caused by mutation in gene SCN5A, which codes for the Nav1.5 Na+ channel. Herein, we have generated a human embryonic stem cell line (WAe009-A-48) carrying a LQTS related mutation in SCN5A (WAe009-A-48). The WAe009-A-48 line maintained stem cell like morphology, pluripotency, normal karyotype and could differentiate into all three germ layers in vivo.
url http://www.sciencedirect.com/science/article/pii/S1873506121000404
work_keys_str_mv AT xiaofeiyang establishmentofhumanembryonicstemcellwae009a48carryingalongqtsyndromemutationinscn5a
AT fujianwu establishmentofhumanembryonicstemcellwae009a48carryingalongqtsyndromemutationinscn5a
AT jiaqizhong establishmentofhumanembryonicstemcellwae009a48carryingalongqtsyndromemutationinscn5a
AT furongli establishmentofhumanembryonicstemcellwae009a48carryingalongqtsyndromemutationinscn5a
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