Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis
IgA anti-CD74 can be a promising marker for diagnosis, assessment of activity and prognosis for ankylosing spondylitis.The aim of the study was to determine the level of IgA anti-CD74 in patients with ankylosing spondylitis and to evaluate its relationships with ankylosing spondylitis activity and c...
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doaj-436e6ebaccd440839be9d6ebcba0030d2021-08-02T09:05:54ZrusIMA-PRESS LLCНаучно-практическая ревматология1995-44841995-44922021-01-0158665866210.47360/1995-4484-2020-658-6622660Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitisV. I. Mazurov0I. Z. Gaydukova1E. A. Vasilenko2E. A. Vasilenko3S. V. Lapin4S. V. Lapin5I. V. Kholopova6M. A. Korolev7North-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityResearch Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesIgA anti-CD74 can be a promising marker for diagnosis, assessment of activity and prognosis for ankylosing spondylitis.The aim of the study was to determine the level of IgA anti-CD74 in patients with ankylosing spondylitis and to evaluate its relationships with ankylosing spondylitis activity and carriership of genetic alleles.Materials and methods. In 48 patients with a reliable diagnosis of ankylosing spondylitis, aged 18 to 69 years were measured the ASDAScrp, BASDAI, level of highly sensitive С-reactive protein, concentration of IgA anti-CD74. The polymorphisms of the genes interleukin (IL)-17A197 a/g, IL-17F7 histidine (His) / arginine (Arg), IL-17F11139 c/g, TNF-a-863, TNFα-308, TNFα-238, IL-1B-31, IL- 4-590, IL-6-174, IL-10-1082, IL-10-592, vascular endothelial growth factor (VEGF)-2578, VEGF-936, matrix metalloproteinase (MMP)2-1306, MMP3-5A6A, MMP9-1562, HLA-B27 were evaluated in their relationships with AS activity and IgA anti-CD74 levels.Results. The mean age of patients was 45.1±14.2 years, male - 72.9%, psoriasis - 10.4%, IBD - 2.1%, BASDAI -2.99±0.28, ASDAS - 2.29±0.16, CRP - 6.5±1.65 mg/L, IgA эпй-СВ74 - 18.6±1.73 U/mL (72.9% of the patients with >12 U/mL). The relationship between an increase in concentration of IgA anti-CD74 and ASDAScrp, BASDAI activity indices, between an increase in the level of CRP and the presence of the IL-17A genotype heterozygous for the AA allele (r=0.965) was determined. CRP did not demonstrate the relationship with the BASDAI.An association of IL-17F-11139 СС and the presence of psoriasis (r=0.870) was established. 93.8% of patients with ankylosing spondylitis were carriers of the homozygous histidine allele IL-17F7 (his/his) and the TNF238 allele (GG).Conclusions. The increase in anti-CD74 IgA level was found in 72.9% of patients with ankylosing spondylitis receiving inhibitors of TNF-a and NSAIDs and associated with clinical and laboratory indicators of ankylosing spondylitis activity and with carriage of the homozygous histidine allele IL-17F7 (his/his) detected in 93.8% of patients. Carriage of TNF-238 GG; TNF-863 CC; HLA-B27; TNF-308 GG; IL-4-590 CC; IL-6-174 CG;MMP9-1562 CC; MMP9-1562 CC; VEGF- 936 CC alleles was not associated with an increase in concentration of IgA anti-CD74. CRP demonstrated an association with IL-17A-197 AA (r=0.965) detected in 29.2% of patients with no correlation with the clinical ankylosing spondylitis activity in patients receiving treatment with iTNF-α and NSAIDs.https://rsp.mediar-press.net/rsp/article/view/2963axial spondyloarthritisankylosing spondylitisanti-cd74il-17 |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
V. I. Mazurov I. Z. Gaydukova E. A. Vasilenko E. A. Vasilenko S. V. Lapin S. V. Lapin I. V. Kholopova M. A. Korolev |
spellingShingle |
V. I. Mazurov I. Z. Gaydukova E. A. Vasilenko E. A. Vasilenko S. V. Lapin S. V. Lapin I. V. Kholopova M. A. Korolev Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis Научно-практическая ревматология axial spondyloarthritis ankylosing spondylitis anti-cd74 il-17 |
author_facet |
V. I. Mazurov I. Z. Gaydukova E. A. Vasilenko E. A. Vasilenko S. V. Lapin S. V. Lapin I. V. Kholopova M. A. Korolev |
author_sort |
V. I. Mazurov |
title |
Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis |
title_short |
Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis |
title_full |
Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis |
title_fullStr |
Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis |
title_full_unstemmed |
Anti-CD74 IGA antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis |
title_sort |
anti-cd74 iga antibodies, genetic polymorphisms and inflammatory activity in ankylosing spondylitis |
publisher |
IMA-PRESS LLC |
series |
Научно-практическая ревматология |
issn |
1995-4484 1995-4492 |
publishDate |
2021-01-01 |
description |
IgA anti-CD74 can be a promising marker for diagnosis, assessment of activity and prognosis for ankylosing spondylitis.The aim of the study was to determine the level of IgA anti-CD74 in patients with ankylosing spondylitis and to evaluate its relationships with ankylosing spondylitis activity and carriership of genetic alleles.Materials and methods. In 48 patients with a reliable diagnosis of ankylosing spondylitis, aged 18 to 69 years were measured the ASDAScrp, BASDAI, level of highly sensitive С-reactive protein, concentration of IgA anti-CD74. The polymorphisms of the genes interleukin (IL)-17A197 a/g, IL-17F7 histidine (His) / arginine (Arg), IL-17F11139 c/g, TNF-a-863, TNFα-308, TNFα-238, IL-1B-31, IL- 4-590, IL-6-174, IL-10-1082, IL-10-592, vascular endothelial growth factor (VEGF)-2578, VEGF-936, matrix metalloproteinase (MMP)2-1306, MMP3-5A6A, MMP9-1562, HLA-B27 were evaluated in their relationships with AS activity and IgA anti-CD74 levels.Results. The mean age of patients was 45.1±14.2 years, male - 72.9%, psoriasis - 10.4%, IBD - 2.1%, BASDAI -2.99±0.28, ASDAS - 2.29±0.16, CRP - 6.5±1.65 mg/L, IgA эпй-СВ74 - 18.6±1.73 U/mL (72.9% of the patients with >12 U/mL). The relationship between an increase in concentration of IgA anti-CD74 and ASDAScrp, BASDAI activity indices, between an increase in the level of CRP and the presence of the IL-17A genotype heterozygous for the AA allele (r=0.965) was determined. CRP did not demonstrate the relationship with the BASDAI.An association of IL-17F-11139 СС and the presence of psoriasis (r=0.870) was established. 93.8% of patients with ankylosing spondylitis were carriers of the homozygous histidine allele IL-17F7 (his/his) and the TNF238 allele (GG).Conclusions. The increase in anti-CD74 IgA level was found in 72.9% of patients with ankylosing spondylitis receiving inhibitors of TNF-a and NSAIDs and associated with clinical and laboratory indicators of ankylosing spondylitis activity and with carriage of the homozygous histidine allele IL-17F7 (his/his) detected in 93.8% of patients. Carriage of TNF-238 GG; TNF-863 CC; HLA-B27; TNF-308 GG; IL-4-590 CC; IL-6-174 CG;MMP9-1562 CC; MMP9-1562 CC; VEGF- 936 CC alleles was not associated with an increase in concentration of IgA anti-CD74. CRP demonstrated an association with IL-17A-197 AA (r=0.965) detected in 29.2% of patients with no correlation with the clinical ankylosing spondylitis activity in patients receiving treatment with iTNF-α and NSAIDs. |
topic |
axial spondyloarthritis ankylosing spondylitis anti-cd74 il-17 |
url |
https://rsp.mediar-press.net/rsp/article/view/2963 |
work_keys_str_mv |
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