Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer
Abstract Background Cervical cancer is a widespread cancer among women worldwide. In this study, we evaluated the role of diffusion weighted magnetic resonance imaging (DWI-MRI) in diagnosis of cervical carcinoma with pathological diagnosis taken as the reference. The study included 70 patients in w...
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doaj-4373f13047fb461e9102b6f950335bdd2021-01-31T16:32:22ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622020-01-015111810.1186/s43055-020-0144-2Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancerSahar Mahmoud Abd elsalam0Omnia Mokhtar1Lamia Adel2Reda Hassan3Manal Ibraheim4Amro Kamal5Radiology Department, Faculty of Medicine, Beni-suef UniversityRadiology Department, National Cancer Institute of CairoRadiology Department, Faculty of Medicine, Cairo UniversityRadiology Department, National Cancer Institute of CairoNational Liver Institute, Menofia UniversitySurgery Department, National Cancer Institute of CairoAbstract Background Cervical cancer is a widespread cancer among women worldwide. In this study, we evaluated the role of diffusion weighted magnetic resonance imaging (DWI-MRI) in diagnosis of cervical carcinoma with pathological diagnosis taken as the reference. The study included 70 patients in whom cancer cervix had been suspected clinically or by transvaginal U/S and confirmed by biopsy. The control group consisted of 40 patients with a normal cervix who performed MRI for other pelvic disorders. Pelvic MR with DWI and dynamic contrast enhanced MRI (DCE-MR) were done for all patients. Results Both DW-MRI and DCE-MRI revealed the same sensitivity, specificity, PPV, and accuracy; 100%, 50%, 97%, and 97%, respectively. The mean ADC value for malignant lesions was (0.82 × 10−3 ± 0.1 SD mm2/s). While the mean ADC value in the control group is (1.56 × 10–3 mm2/s). ADC value of (1.07 × 10−3 mm2/s) is a cut-off between normal cervical tissue& malignant cervical lesion with a sensitivity 97% and specificity 95.5% Conclusion Each of the (DW-MRI) and (DCE-MRI) sequences when added to the non-contrast MRI sequences in the estimation of cancer cervix had elicited the same sensitivity, specificity, and accuracy. DW–MRI was significantly beneficial in terms of diagnostic performance. For patients who cannot receive contrast medium, dynamic contrast-enhanced imaging can be replaced by DWI. The ADC value in case of cervical cancer was significantly lower than in the non-affected cervical tissue.https://doi.org/10.1186/s43055-020-0144-2Cervical carcinoma DW-MRIACD valueDCE-MRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sahar Mahmoud Abd elsalam Omnia Mokhtar Lamia Adel Reda Hassan Manal Ibraheim Amro Kamal |
spellingShingle |
Sahar Mahmoud Abd elsalam Omnia Mokhtar Lamia Adel Reda Hassan Manal Ibraheim Amro Kamal Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer The Egyptian Journal of Radiology and Nuclear Medicine Cervical carcinoma DW-MRI ACD value DCE-MRI |
author_facet |
Sahar Mahmoud Abd elsalam Omnia Mokhtar Lamia Adel Reda Hassan Manal Ibraheim Amro Kamal |
author_sort |
Sahar Mahmoud Abd elsalam |
title |
Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer |
title_short |
Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer |
title_full |
Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer |
title_fullStr |
Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer |
title_full_unstemmed |
Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer |
title_sort |
impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Radiology and Nuclear Medicine |
issn |
2090-4762 |
publishDate |
2020-01-01 |
description |
Abstract Background Cervical cancer is a widespread cancer among women worldwide. In this study, we evaluated the role of diffusion weighted magnetic resonance imaging (DWI-MRI) in diagnosis of cervical carcinoma with pathological diagnosis taken as the reference. The study included 70 patients in whom cancer cervix had been suspected clinically or by transvaginal U/S and confirmed by biopsy. The control group consisted of 40 patients with a normal cervix who performed MRI for other pelvic disorders. Pelvic MR with DWI and dynamic contrast enhanced MRI (DCE-MR) were done for all patients. Results Both DW-MRI and DCE-MRI revealed the same sensitivity, specificity, PPV, and accuracy; 100%, 50%, 97%, and 97%, respectively. The mean ADC value for malignant lesions was (0.82 × 10−3 ± 0.1 SD mm2/s). While the mean ADC value in the control group is (1.56 × 10–3 mm2/s). ADC value of (1.07 × 10−3 mm2/s) is a cut-off between normal cervical tissue& malignant cervical lesion with a sensitivity 97% and specificity 95.5% Conclusion Each of the (DW-MRI) and (DCE-MRI) sequences when added to the non-contrast MRI sequences in the estimation of cancer cervix had elicited the same sensitivity, specificity, and accuracy. DW–MRI was significantly beneficial in terms of diagnostic performance. For patients who cannot receive contrast medium, dynamic contrast-enhanced imaging can be replaced by DWI. The ADC value in case of cervical cancer was significantly lower than in the non-affected cervical tissue. |
topic |
Cervical carcinoma DW-MRI ACD value DCE-MRI |
url |
https://doi.org/10.1186/s43055-020-0144-2 |
work_keys_str_mv |
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