The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction
<p><strong>Background:</strong> Movement disorders, particularly those associated with basal ganglia disease, have a high rate of comorbid neuropsychiatric illness.</p><p><strong>Methods:</strong> We consider the pathophysiological basis of...
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Ubiquity Press
2013-09-01
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Series: | Tremor and Other Hyperkinetic Movements |
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doaj-437bc2dec7354dabae8e4fcbad8dd1622021-04-02T10:06:56ZengUbiquity PressTremor and Other Hyperkinetic Movements2160-82882013-09-01310.7916/D8SN07PK99The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of DysfunctionBradleigh D. Hayhow0Islam K. Hassan1Jeffrey C. Looi2Francesco Gaillard3Dennis Velakoulis4Mark Walterfang5Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, AustraliaNeuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, AustraliaAcademic Unit of Psychiatry & Addiction Medicine, Australian National University Medical School, Canberra Hospital, Canberra, AustraliaDepartment of Radiology, Royal Melbourne Hospital, Melbourne, AustraliaNeuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Australia Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, AustraliaNeuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Australia Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia<p><strong>Background:</strong> Movement disorders, particularly those associated with basal ganglia disease, have a high rate of comorbid neuropsychiatric illness.</p><p><strong>Methods:</strong> We consider the pathophysiological basis of the comorbidity between movement disorders and neuropsychiatric illness by 1) reviewing the epidemiology of neuropsychiatric illness in a range of hyperkinetic movement disorders, and 2) correlating findings to evidence from studies that have utilized modern neuroimaging techniques to investigate these disorders. In addition to diseases classically associated with basal ganglia pathology, such as Huntington disease, Wilson disease, the neuroacanthocytoses, and diseases of brain iron accumulation, we include diseases associated with pathology of subcortical white matter tracts, brain stem nuclei, and the cerebellum, such as metachromatic leukodystrophy, dentatorubropallidoluysian atrophy, and the spinocerebellar ataxias.</p><p><strong>Conclusions:</strong> Neuropsychiatric symptoms are integral to a thorough phenomenological account of hyperkinetic movement disorders. Drawing on modern theories of cortico-subcortical circuits, we argue that these disorders can be conceptualized as disorders of complex subcortical networks with distinct functional architectures. Damage to any component of these complex information-processing networks can have variable and often profound consequences for the function of more remote neural structures, creating a diverse but nonetheless rational pattern of clinical symptomatology.</p><br />https://tremorjournal.org/index.php/tremor/article/view/175 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bradleigh D. Hayhow Islam K. Hassan Jeffrey C. Looi Francesco Gaillard Dennis Velakoulis Mark Walterfang |
spellingShingle |
Bradleigh D. Hayhow Islam K. Hassan Jeffrey C. Looi Francesco Gaillard Dennis Velakoulis Mark Walterfang The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction Tremor and Other Hyperkinetic Movements |
author_facet |
Bradleigh D. Hayhow Islam K. Hassan Jeffrey C. Looi Francesco Gaillard Dennis Velakoulis Mark Walterfang |
author_sort |
Bradleigh D. Hayhow |
title |
The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction |
title_short |
The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction |
title_full |
The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction |
title_fullStr |
The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction |
title_full_unstemmed |
The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction |
title_sort |
neuropsychiatry of hyperkinetic movement disorders: insights from neuroimaging into the neural circuit bases of dysfunction |
publisher |
Ubiquity Press |
series |
Tremor and Other Hyperkinetic Movements |
issn |
2160-8288 |
publishDate |
2013-09-01 |
description |
<p><strong>Background:</strong> Movement disorders, particularly those associated with basal ganglia disease, have a high rate of comorbid neuropsychiatric illness.</p><p><strong>Methods:</strong> We consider the pathophysiological basis of the comorbidity between movement disorders and neuropsychiatric illness by 1) reviewing the epidemiology of neuropsychiatric illness in a range of hyperkinetic movement disorders, and 2) correlating findings to evidence from studies that have utilized modern neuroimaging techniques to investigate these disorders. In addition to diseases classically associated with basal ganglia pathology, such as Huntington disease, Wilson disease, the neuroacanthocytoses, and diseases of brain iron accumulation, we include diseases associated with pathology of subcortical white matter tracts, brain stem nuclei, and the cerebellum, such as metachromatic leukodystrophy, dentatorubropallidoluysian atrophy, and the spinocerebellar ataxias.</p><p><strong>Conclusions:</strong> Neuropsychiatric symptoms are integral to a thorough phenomenological account of hyperkinetic movement disorders. Drawing on modern theories of cortico-subcortical circuits, we argue that these disorders can be conceptualized as disorders of complex subcortical networks with distinct functional architectures. Damage to any component of these complex information-processing networks can have variable and often profound consequences for the function of more remote neural structures, creating a diverse but nonetheless rational pattern of clinical symptomatology.</p><br /> |
url |
https://tremorjournal.org/index.php/tremor/article/view/175 |
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