Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity
Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to intro...
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Tehran University of Medical Sciences
2013-04-01
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doaj-437c1afa0c3b4d9a8857deb432cec1032020-11-25T03:28:33ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942013-04-01514Pemphigus Vulgaris Activity Score and Assessment of Convergent ValidityCheyda Chams-Davatchi0Ziba Rahbar1Maryam Daneshpazhooh2Seyed Mohammad Ali Mortazavizadeh3Maryam Akhyani4Nafiseh Esmaili5Kamran Balighi6Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS) measurement and to assess the convergent validity with the experts' opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky's sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky's sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician's global assessment (PGA). The convergent validity with experts' opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876). PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris. https://acta.tums.ac.ir/index.php/acta/article/view/4458ExpertPemphigusPhysician’s Global AssessmentValidity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheyda Chams-Davatchi Ziba Rahbar Maryam Daneshpazhooh Seyed Mohammad Ali Mortazavizadeh Maryam Akhyani Nafiseh Esmaili Kamran Balighi |
spellingShingle |
Cheyda Chams-Davatchi Ziba Rahbar Maryam Daneshpazhooh Seyed Mohammad Ali Mortazavizadeh Maryam Akhyani Nafiseh Esmaili Kamran Balighi Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity Acta Medica Iranica Expert Pemphigus Physician’s Global Assessment Validity |
author_facet |
Cheyda Chams-Davatchi Ziba Rahbar Maryam Daneshpazhooh Seyed Mohammad Ali Mortazavizadeh Maryam Akhyani Nafiseh Esmaili Kamran Balighi |
author_sort |
Cheyda Chams-Davatchi |
title |
Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity |
title_short |
Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity |
title_full |
Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity |
title_fullStr |
Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity |
title_full_unstemmed |
Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity |
title_sort |
pemphigus vulgaris activity score and assessment of convergent validity |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2013-04-01 |
description |
Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS) measurement and to assess the convergent validity with the experts' opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky's sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky's sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician's global assessment (PGA). The convergent validity with experts' opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876). PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris.
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topic |
Expert Pemphigus Physician’s Global Assessment Validity |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/4458 |
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