Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults
Emerging evidence suggests a role for the gut microbiota in glucose metabolism and diabetes. Few studies have examined the associations between the faecal microbiome and insulin sensitivity and secretion using gold-standard methods in high-risk populations prior to diabetes onset. We investigated th...
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doaj-4388373537e44092b1b363fefd19f6292020-11-24T22:11:29ZengMDPI AGJournal of Clinical Medicine2077-03832019-04-018445210.3390/jcm8040452jcm8040452Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese AdultsNegar Naderpoor0Aya Mousa1Luisa F. Gomez-Arango2Helen L. Barrett3Marloes Dekker Nitert4Barbora de Courten5Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, AustraliaMonash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, AustraliaSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia 4072, AustraliaEndocrinology department and Mater Research, Mater Hospital, South Brisbane 4101, AustraliaSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia 4072, AustraliaMonash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, AustraliaEmerging evidence suggests a role for the gut microbiota in glucose metabolism and diabetes. Few studies have examined the associations between the faecal microbiome and insulin sensitivity and secretion using gold-standard methods in high-risk populations prior to diabetes onset. We investigated the relationships between faecal microbiota composition (16S rRNA sequencing) and gold-standard measures of insulin sensitivity (hyperinsulinaemic-euglycaemic clamp) and insulin secretion (intravenous glucose tolerance test) in 38 overweight or obese otherwise healthy individuals. Genus <i>Clostridium</i> was positively associated with insulin sensitivity, and genera <i>Dialister</i> and <i>Phascolarctobacterium</i> were related to both insulin sensitivity and secretion. Insulin sensitivity was associated with a higher abundance of <i>Phascolarctobacterium</i> and lower abundance of <i>Dialister</i>. Those with higher insulin secretion had a higher abundance of <i>Dialister</i> and lower abundance of <i>Bifidobacterium</i>, compared to those with lower insulin secretion. Body mass index (BMI) was positively correlated with <i>Streptococcus</i> abundance whereas <i>Coprococcus</i> abundance was negatively correlated to BMI and percent body fat. These results suggest that faecal microbiota is related to insulin sensitivity and secretion in overweight or obese adults. These correlations are distinct although partially overlapping, suggesting different pathophysiological pathways. Our findings can inform future trials aiming to manipulate gut microbiome to improve insulin sensitivity and secretion and prevent type 2 diabetes.https://www.mdpi.com/2077-0383/8/4/452faecal microbiotabody mass indexpercent body fatinsulin secretioninsulin sensitivityhyperinsulinaemic-euglycaemic clamp |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Negar Naderpoor Aya Mousa Luisa F. Gomez-Arango Helen L. Barrett Marloes Dekker Nitert Barbora de Courten |
spellingShingle |
Negar Naderpoor Aya Mousa Luisa F. Gomez-Arango Helen L. Barrett Marloes Dekker Nitert Barbora de Courten Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults Journal of Clinical Medicine faecal microbiota body mass index percent body fat insulin secretion insulin sensitivity hyperinsulinaemic-euglycaemic clamp |
author_facet |
Negar Naderpoor Aya Mousa Luisa F. Gomez-Arango Helen L. Barrett Marloes Dekker Nitert Barbora de Courten |
author_sort |
Negar Naderpoor |
title |
Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults |
title_short |
Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults |
title_full |
Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults |
title_fullStr |
Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults |
title_full_unstemmed |
Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults |
title_sort |
faecal microbiota are related to insulin sensitivity and secretion in overweight or obese adults |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-04-01 |
description |
Emerging evidence suggests a role for the gut microbiota in glucose metabolism and diabetes. Few studies have examined the associations between the faecal microbiome and insulin sensitivity and secretion using gold-standard methods in high-risk populations prior to diabetes onset. We investigated the relationships between faecal microbiota composition (16S rRNA sequencing) and gold-standard measures of insulin sensitivity (hyperinsulinaemic-euglycaemic clamp) and insulin secretion (intravenous glucose tolerance test) in 38 overweight or obese otherwise healthy individuals. Genus <i>Clostridium</i> was positively associated with insulin sensitivity, and genera <i>Dialister</i> and <i>Phascolarctobacterium</i> were related to both insulin sensitivity and secretion. Insulin sensitivity was associated with a higher abundance of <i>Phascolarctobacterium</i> and lower abundance of <i>Dialister</i>. Those with higher insulin secretion had a higher abundance of <i>Dialister</i> and lower abundance of <i>Bifidobacterium</i>, compared to those with lower insulin secretion. Body mass index (BMI) was positively correlated with <i>Streptococcus</i> abundance whereas <i>Coprococcus</i> abundance was negatively correlated to BMI and percent body fat. These results suggest that faecal microbiota is related to insulin sensitivity and secretion in overweight or obese adults. These correlations are distinct although partially overlapping, suggesting different pathophysiological pathways. Our findings can inform future trials aiming to manipulate gut microbiome to improve insulin sensitivity and secretion and prevent type 2 diabetes. |
topic |
faecal microbiota body mass index percent body fat insulin secretion insulin sensitivity hyperinsulinaemic-euglycaemic clamp |
url |
https://www.mdpi.com/2077-0383/8/4/452 |
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