Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors
<b>: </b>In recent years, it has become increasingly evident that cancer cells and the local microenvironment are crucial in the development and progression of tumors. One of the major components of the tumor microenvironment is the extracellular matrix (ECM), which comprises a complex m...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-01-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/8/2/81 |
id |
doaj-43913b92dcd047c9bfa4639176c1d8db |
---|---|
record_format |
Article |
spelling |
doaj-43913b92dcd047c9bfa4639176c1d8db2020-11-25T00:03:26ZengMDPI AGCells2073-44092019-01-01828110.3390/cells8020081cells8020081Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid TumorsMarta Giussani0Tiziana Triulzi1Gabriella Sozzi2Elda Tagliabue3Molecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di, 20133 Milano, ItalyMolecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di, 20133 Milano, ItalyTumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di, 20133 Milano, ItalyMolecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di, 20133 Milano, Italy<b>: </b>In recent years, it has become increasingly evident that cancer cells and the local microenvironment are crucial in the development and progression of tumors. One of the major components of the tumor microenvironment is the extracellular matrix (ECM), which comprises a complex mixture of components, including proteins, glycoproteins, proteoglycans, and polysaccharides. In addition to providing structural and biochemical support to tumor tissue, the ECM undergoes remodeling that alters the biochemical and mechanical properties of the tumor microenvironment and contributes to tumor progression and resistance to therapy. A novel concept has emerged, in which tumor-driven ECM remodeling affects the release of ECM components into peripheral blood, the levels of which are potential diagnostic or prognostic markers for tumors. This review discusses the most recent evidence on ECM remodeling-derived signals that are detectable in the bloodstream, as new early diagnostic and risk prediction tools for the most frequent solid cancers.https://www.mdpi.com/2073-4409/8/2/81extracellular matrixcirculating biomarkersdiagnosisprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Giussani Tiziana Triulzi Gabriella Sozzi Elda Tagliabue |
spellingShingle |
Marta Giussani Tiziana Triulzi Gabriella Sozzi Elda Tagliabue Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors Cells extracellular matrix circulating biomarkers diagnosis prognosis |
author_facet |
Marta Giussani Tiziana Triulzi Gabriella Sozzi Elda Tagliabue |
author_sort |
Marta Giussani |
title |
Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors |
title_short |
Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors |
title_full |
Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors |
title_fullStr |
Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors |
title_full_unstemmed |
Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors |
title_sort |
tumor extracellular matrix remodeling: new perspectives as a circulating tool in the diagnosis and prognosis of solid tumors |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2019-01-01 |
description |
<b>: </b>In recent years, it has become increasingly evident that cancer cells and the local microenvironment are crucial in the development and progression of tumors. One of the major components of the tumor microenvironment is the extracellular matrix (ECM), which comprises a complex mixture of components, including proteins, glycoproteins, proteoglycans, and polysaccharides. In addition to providing structural and biochemical support to tumor tissue, the ECM undergoes remodeling that alters the biochemical and mechanical properties of the tumor microenvironment and contributes to tumor progression and resistance to therapy. A novel concept has emerged, in which tumor-driven ECM remodeling affects the release of ECM components into peripheral blood, the levels of which are potential diagnostic or prognostic markers for tumors. This review discusses the most recent evidence on ECM remodeling-derived signals that are detectable in the bloodstream, as new early diagnostic and risk prediction tools for the most frequent solid cancers. |
topic |
extracellular matrix circulating biomarkers diagnosis prognosis |
url |
https://www.mdpi.com/2073-4409/8/2/81 |
work_keys_str_mv |
AT martagiussani tumorextracellularmatrixremodelingnewperspectivesasacirculatingtoolinthediagnosisandprognosisofsolidtumors AT tizianatriulzi tumorextracellularmatrixremodelingnewperspectivesasacirculatingtoolinthediagnosisandprognosisofsolidtumors AT gabriellasozzi tumorextracellularmatrixremodelingnewperspectivesasacirculatingtoolinthediagnosisandprognosisofsolidtumors AT eldatagliabue tumorextracellularmatrixremodelingnewperspectivesasacirculatingtoolinthediagnosisandprognosisofsolidtumors |
_version_ |
1725433928705114112 |