Serum cytokines, T lymphocyte subsets and STAT3 function in patients with herpes zoster as well as the intervention effect of mouse nerve growth factor
Objective: To assess the levels of serum cytokines, T lymphocyte subsets and STAT3 in patients with herpes zoster as well as the intervention effect of mouse nerve growth factor. Methods: A total of 102 patients with herpes zoster were selected as observation group and received mouse nerve growth...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2016-07-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201613/7.pdf |
Summary: | Objective: To assess the levels of serum cytokines, T lymphocyte subsets and STAT3 in
patients with herpes zoster as well as the intervention effect of mouse nerve growth factor.
Methods: A total of 102 patients with herpes zoster were selected as observation group and
received mouse nerve growth factor intervention, and 100 cases of normal people who received
physical examination in our hospital during the same period as the healthy control group. The
levels of serum Th1/Th2 cytokines, IgG subclass and complements and T lymphocyte subsets
as well as STAT3 function of observation group before and after treatment and healthy control
group were detected. Results: Serum IL-2 and γ-IFN levels of observation group after
treatment were higher than those before treatment while IL-4, IL-5, IL-10 and TNF-α毩 levels
were lower than those before treatment (P<0.05); serum IgG1, IgG3, IgG4, C3 and C4 values
of observation group after treatment were higher than those before treatment while IgG2 value
was lower than that before treatment (P<0.05); CD3, CD4 and CD4/CD8 levels of observation
group after treatment were higher than those before treatment while CD8 level was lower than
that before treatment (P<0.05); STAT3, p-STAT3 and JAK2 expression levels of observation
group after treatment were lower than those before treatment (P<0.05). Conclusions: There
are abnormal immune system and STAT3 signaling pathway function in patients with herpes
zoster, and mouse nerve growth factor intervention can restore multisystem balance and
accelerate disease rehabilitation, and has positive clinical significance. |
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ISSN: | 1007-1237 1007-1237 |