Adhesive Cements That Bond Soft Tissue Ex Vivo
The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1),...
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doaj-43a6d1edb7f343fea4797f0cf7482c572020-11-25T01:55:47ZengMDPI AGMaterials1996-19442019-08-011215247310.3390/ma12152473ma12152473Adhesive Cements That Bond Soft Tissue Ex VivoXiuwen Liu0Michael Pujari-Palmer1David Wenner2Philip Procter3Gerard Insley4Håkan Engqvist5Applied Material Science, Department of Engineering, Uppsala University, 75121 Uppsala, SwedenApplied Material Science, Department of Engineering, Uppsala University, 75121 Uppsala, SwedenApplied Material Science, Department of Engineering, Uppsala University, 75121 Uppsala, SwedenApplied Material Science, Department of Engineering, Uppsala University, 75121 Uppsala, SwedenApplied Material Science, Department of Engineering, Uppsala University, 75121 Uppsala, SwedenApplied Material Science, Department of Engineering, Uppsala University, 75121 Uppsala, SwedenThe aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. αTCP PMCs reached a final LSS of ≈110 kPa. In soft tissues, stronger bond strengths were obtained with αTCP PMCs containing large amounts of amino acid (70−90 mol%), in contrast to prior studies in calcified tissues (30−50 mol%). When αTCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30−50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.https://www.mdpi.com/1996-1944/12/15/2473tissue adhesivephosphoserinephosphoserine modified cementbiomaterialbioceramiclap shearbone cementsilicatecalcium phosphateself-setting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiuwen Liu Michael Pujari-Palmer David Wenner Philip Procter Gerard Insley Håkan Engqvist |
spellingShingle |
Xiuwen Liu Michael Pujari-Palmer David Wenner Philip Procter Gerard Insley Håkan Engqvist Adhesive Cements That Bond Soft Tissue Ex Vivo Materials tissue adhesive phosphoserine phosphoserine modified cement biomaterial bioceramic lap shear bone cement silicate calcium phosphate self-setting |
author_facet |
Xiuwen Liu Michael Pujari-Palmer David Wenner Philip Procter Gerard Insley Håkan Engqvist |
author_sort |
Xiuwen Liu |
title |
Adhesive Cements That Bond Soft Tissue Ex Vivo |
title_short |
Adhesive Cements That Bond Soft Tissue Ex Vivo |
title_full |
Adhesive Cements That Bond Soft Tissue Ex Vivo |
title_fullStr |
Adhesive Cements That Bond Soft Tissue Ex Vivo |
title_full_unstemmed |
Adhesive Cements That Bond Soft Tissue Ex Vivo |
title_sort |
adhesive cements that bond soft tissue ex vivo |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2019-08-01 |
description |
The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. αTCP PMCs reached a final LSS of ≈110 kPa. In soft tissues, stronger bond strengths were obtained with αTCP PMCs containing large amounts of amino acid (70−90 mol%), in contrast to prior studies in calcified tissues (30−50 mol%). When αTCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30−50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues. |
topic |
tissue adhesive phosphoserine phosphoserine modified cement biomaterial bioceramic lap shear bone cement silicate calcium phosphate self-setting |
url |
https://www.mdpi.com/1996-1944/12/15/2473 |
work_keys_str_mv |
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