Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae

• Main Authors: Yibao Li, Lei Zhu, Yulan Fan, Yayun Li, Linxiu Cheng, Wei Liu, Xun Li, Xiaolin Fan
• Format: Article
• Language: English
• Published: MDPI AG 2016-03-01
• Series: Nanomaterials
• Subjects: hydrogel; drug release; long-term release time; anti-cercariae
• Online Access: http://www.mdpi.com/2079-4991/6/3/46

A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π–π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indicated that the drug-loaded hydrogels show large drug loadings, long-term release time and relatively higher efficiency to anti-cercariae in the water environment.