Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives
Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neu...
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Format: | Article |
Language: | English |
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MDPI AG
2021-01-01
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Series: | Brain Sciences |
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Online Access: | https://www.mdpi.com/2076-3425/11/1/84 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giuseppe Roberto Giammalva Cesare Gagliardo Salvatore Marrone Federica Paolini Rosa Maria Gerardi Giuseppe Emmanuele Umana Kaan Yağmurlu Bipin Chaurasia Gianluca Scalia Federico Midiri Ludovico La Grutta Luigi Basile Carlo Gulì Domenico Messina Maria Angela Pino Francesca Graziano Silvana Tumbiolo Domenico Gerardo Iacopino Rosario Maugeri |
spellingShingle |
Giuseppe Roberto Giammalva Cesare Gagliardo Salvatore Marrone Federica Paolini Rosa Maria Gerardi Giuseppe Emmanuele Umana Kaan Yağmurlu Bipin Chaurasia Gianluca Scalia Federico Midiri Ludovico La Grutta Luigi Basile Carlo Gulì Domenico Messina Maria Angela Pino Francesca Graziano Silvana Tumbiolo Domenico Gerardo Iacopino Rosario Maugeri Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives Brain Sciences tcMRgFUS HIFU LIFU focused ultrasound neuro-oncology neurodegenerative diseases |
author_facet |
Giuseppe Roberto Giammalva Cesare Gagliardo Salvatore Marrone Federica Paolini Rosa Maria Gerardi Giuseppe Emmanuele Umana Kaan Yağmurlu Bipin Chaurasia Gianluca Scalia Federico Midiri Ludovico La Grutta Luigi Basile Carlo Gulì Domenico Messina Maria Angela Pino Francesca Graziano Silvana Tumbiolo Domenico Gerardo Iacopino Rosario Maugeri |
author_sort |
Giuseppe Roberto Giammalva |
title |
Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives |
title_short |
Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives |
title_full |
Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives |
title_fullStr |
Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives |
title_full_unstemmed |
Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives |
title_sort |
focused ultrasound in neuroscience. state of the art and future perspectives |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-01-01 |
description |
Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neurosurgical applications, tcMRgFUS has been successfully adopted as a non-invasive procedure for ablative purposes such as thalamotomy, pallidotomy, and subthalamotomy for movement disorders. Several studies confirmed the effectiveness of tcMRgFUS in the treatment of several neurological conditions, ranging from motor disorders to psychiatric disorders. Moreover, using low-frequencies tcMRgFUS systems temporarily disrupts the blood–brain barrier, making this procedure suitable in neuro-oncology and neurodegenerative disease for controlled drug delivery. Nowadays, tcMRgFUS represents one of the most promising and fascinating technologies in neuroscience. Since it is an emerging technology, tcMRgFUS is still the subject of countless disparate studies, even if its effectiveness has been already proven in many experimental and therapeutic fields. Therefore, although many studies have been carried out, many others are still needed to increase the degree of knowledge of the innumerable potentials of tcMRgFUS and thus expand the future fields of application of this technology. |
topic |
tcMRgFUS HIFU LIFU focused ultrasound neuro-oncology neurodegenerative diseases |
url |
https://www.mdpi.com/2076-3425/11/1/84 |
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doaj-43adbe52bdf54dcb9a213d59729ead1a2021-01-11T00:00:22ZengMDPI AGBrain Sciences2076-34252021-01-0111848410.3390/brainsci11010084Focused Ultrasound in Neuroscience. State of the Art and Future PerspectivesGiuseppe Roberto Giammalva0Cesare Gagliardo1Salvatore Marrone2Federica Paolini3Rosa Maria Gerardi4Giuseppe Emmanuele Umana5Kaan Yağmurlu6Bipin Chaurasia7Gianluca Scalia8Federico Midiri9Ludovico La Grutta10Luigi Basile11Carlo Gulì12Domenico Messina13Maria Angela Pino14Francesca Graziano15Silvana Tumbiolo16Domenico Gerardo Iacopino17Rosario Maugeri18Neurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalySection of Radiological Sciences, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Neurosurgery, Cannizzaro Hospital, 95126 Catania, ItalyDepartments of Neuroscience and Neurosurgery, University of Virginia Health System, Charlottesville, VA 22903, USADepartment of Neurosurgery, Neurosurgery Clinic, Birgunj 44300, NepalDepartment of Neurosurgery, Highly Specialized Hospital of National Importance “Garibaldi”, 95122 Catania, ItalySection of Radiological Sciences, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-ProMISE, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Neurosurgery, Highly Specialized Hospital of National Importance “Garibaldi”, 95122 Catania, ItalyDivision of Neurosurgery, Villa Sofia Hospital, 90146 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyTranscranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neurosurgical applications, tcMRgFUS has been successfully adopted as a non-invasive procedure for ablative purposes such as thalamotomy, pallidotomy, and subthalamotomy for movement disorders. Several studies confirmed the effectiveness of tcMRgFUS in the treatment of several neurological conditions, ranging from motor disorders to psychiatric disorders. Moreover, using low-frequencies tcMRgFUS systems temporarily disrupts the blood–brain barrier, making this procedure suitable in neuro-oncology and neurodegenerative disease for controlled drug delivery. Nowadays, tcMRgFUS represents one of the most promising and fascinating technologies in neuroscience. Since it is an emerging technology, tcMRgFUS is still the subject of countless disparate studies, even if its effectiveness has been already proven in many experimental and therapeutic fields. Therefore, although many studies have been carried out, many others are still needed to increase the degree of knowledge of the innumerable potentials of tcMRgFUS and thus expand the future fields of application of this technology.https://www.mdpi.com/2076-3425/11/1/84tcMRgFUSHIFULIFUfocused ultrasoundneuro-oncologyneurodegenerative diseases |