Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate

Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate

Precise orchestration of gene expression regulation upon DNA damage is essential for genome integrity. Here the authors identify a novel widespread stress-triggered defence mechanism that promotes rapid transcription-driven genomic surveillance thus limiting mutagenesis and shaping cancer genomes.

Bibliographic Details
Main Authors: Matthieu D. Lavigne, Dimitris Konstantopoulos, Katerina Z. Ntakou-Zamplara, Anastasios Liakos, Maria Fousteri
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02145-4
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spelling doaj-43adcd781e174d94a8fcc1b10dd0a0dd2021-05-11T07:15:15ZengNature Publishing GroupNature Communications2041-17232017-12-018111510.1038/s41467-017-02145-4Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rateMatthieu D. Lavigne0Dimitris Konstantopoulos1Katerina Z. Ntakou-Zamplara2Anastasios Liakos3Maria Fousteri4Biomedical Sciences Research Center ‘Alexander Fleming’Biomedical Sciences Research Center ‘Alexander Fleming’Biomedical Sciences Research Center ‘Alexander Fleming’Biomedical Sciences Research Center ‘Alexander Fleming’Biomedical Sciences Research Center ‘Alexander Fleming’Precise orchestration of gene expression regulation upon DNA damage is essential for genome integrity. Here the authors identify a novel widespread stress-triggered defence mechanism that promotes rapid transcription-driven genomic surveillance thus limiting mutagenesis and shaping cancer genomes.https://doi.org/10.1038/s41467-017-02145-4
collection DOAJ
language English
format Article
sources DOAJ
author Matthieu D. Lavigne
Dimitris Konstantopoulos
Katerina Z. Ntakou-Zamplara
Anastasios Liakos
Maria Fousteri
spellingShingle Matthieu D. Lavigne
Dimitris Konstantopoulos
Katerina Z. Ntakou-Zamplara
Anastasios Liakos
Maria Fousteri
Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
Nature Communications
author_facet Matthieu D. Lavigne
Dimitris Konstantopoulos
Katerina Z. Ntakou-Zamplara
Anastasios Liakos
Maria Fousteri
author_sort Matthieu D. Lavigne
title Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_short Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_full Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_fullStr Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_full_unstemmed Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
title_sort global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Precise orchestration of gene expression regulation upon DNA damage is essential for genome integrity. Here the authors identify a novel widespread stress-triggered defence mechanism that promotes rapid transcription-driven genomic surveillance thus limiting mutagenesis and shaping cancer genomes.
url https://doi.org/10.1038/s41467-017-02145-4
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AT katerinazntakouzamplara globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate
AT anastasiosliakos globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate
AT mariafousteri globalunleashingoftranscriptionelongationwavesinresponsetogenotoxicstressrestrictssomaticmutationrate
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