The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number

The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number

Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated. E3 ubiquitin ligases have been implicated in controlling the levels of several duplication factors, including...

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Bibliographic Details
Main Authors: Christian Arquint, Fabien Cubizolles, Agathe Morand, Alexander Schmidt, Erich A. Nigg
Format: Article
Language:English
Published: The Royal Society 2018-02-01
Series:Open Biology
Subjects:
scf-βtrcp
stil
cdk2
centriole duplication
centrosome
centriole number
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170253

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