Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series

• Main Authors: Jiunn‐Wei Wang, Yao‐Kuang Wang, Faming Zhang, Yu‐Chung Su, Jaw‐Yuan Wang, Deng‐Chyang Wu, Wen‐Hung Hsu
• Format: Article
• Language: English
• Published: Wiley 2019-09-01
• Series: Kaohsiung Journal of Medical Sciences
• Subjects: Clostridium difficile infection; fecal microbiota transplantation; inflammatory bowel disease; transendoscopic enteral tubing
• Online Access: https://doi.org/10.1002/kjm2.12094
• ISSN: 1607-551X; 2410-8650

Abstract Current studies have proven the strong association between gut microbiota dysbiosis and the pathogenesis of gastrointestinal diseases. Fecal microbiota transplantation (FMT) from a healthy donor is a promising therapeutic strategy to change and restore composition of the recipient's gut microbiota. Rapidly increasing clinical literatures confirmed the truth of the benefits of FMT on recurrent Clostridium difficile infection (rCDI) and inflammatory bowel disease. This article retrospectively reviewed nine cases (four cases had ulcerative colitis [UC], five cases had rCDI) who received FMT in Kaohsiung Medical University Hospital from April 2016 to November 2018. We summarized the procedure including donor selection, fecal materials preparation, transplantation delivery methods, and clinical outcomes. All of the four UC cases got clinical improvement and four rCDI cases achieved clinical remission after FMT. The other one rCDI case remained positive stool Toxin A+B result after FMT, and got remission after salvage treatment with fidaxomicin. FMT is considered to be a well‐tolerated adjuvant treatment for UC and effective salvage treatment for rCDI in our initial experience. Multiple infusions of FMT in UC and rCDI might have exceptional clinical efficiency, and enteral tube insertion could be a useful method to reach this goal and make multiple sessions of FMT easier.