Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series
Abstract Current studies have proven the strong association between gut microbiota dysbiosis and the pathogenesis of gastrointestinal diseases. Fecal microbiota transplantation (FMT) from a healthy donor is a promising therapeutic strategy to change and restore composition of the recipient's gu...
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Online Access: | https://doi.org/10.1002/kjm2.12094 |
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doaj-43b287732e5a426c957a00a3455740802020-11-25T00:44:21ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502019-09-0135956657110.1002/kjm2.12094Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case seriesJiunn‐Wei Wang0Yao‐Kuang Wang1Faming Zhang2Yu‐Chung Su3Jaw‐Yuan Wang4Deng‐Chyang Wu5Wen‐Hung Hsu6Division of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University Nanjing ChinaDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Colorectal Surgery, Department of Surgery Kaohsiung Medical University, Hospital Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanAbstract Current studies have proven the strong association between gut microbiota dysbiosis and the pathogenesis of gastrointestinal diseases. Fecal microbiota transplantation (FMT) from a healthy donor is a promising therapeutic strategy to change and restore composition of the recipient's gut microbiota. Rapidly increasing clinical literatures confirmed the truth of the benefits of FMT on recurrent Clostridium difficile infection (rCDI) and inflammatory bowel disease. This article retrospectively reviewed nine cases (four cases had ulcerative colitis [UC], five cases had rCDI) who received FMT in Kaohsiung Medical University Hospital from April 2016 to November 2018. We summarized the procedure including donor selection, fecal materials preparation, transplantation delivery methods, and clinical outcomes. All of the four UC cases got clinical improvement and four rCDI cases achieved clinical remission after FMT. The other one rCDI case remained positive stool Toxin A+B result after FMT, and got remission after salvage treatment with fidaxomicin. FMT is considered to be a well‐tolerated adjuvant treatment for UC and effective salvage treatment for rCDI in our initial experience. Multiple infusions of FMT in UC and rCDI might have exceptional clinical efficiency, and enteral tube insertion could be a useful method to reach this goal and make multiple sessions of FMT easier.https://doi.org/10.1002/kjm2.12094Clostridium difficile infectionfecal microbiota transplantationinflammatory bowel diseasetransendoscopic enteral tubing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiunn‐Wei Wang Yao‐Kuang Wang Faming Zhang Yu‐Chung Su Jaw‐Yuan Wang Deng‐Chyang Wu Wen‐Hung Hsu |
spellingShingle |
Jiunn‐Wei Wang Yao‐Kuang Wang Faming Zhang Yu‐Chung Su Jaw‐Yuan Wang Deng‐Chyang Wu Wen‐Hung Hsu Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series Kaohsiung Journal of Medical Sciences Clostridium difficile infection fecal microbiota transplantation inflammatory bowel disease transendoscopic enteral tubing |
author_facet |
Jiunn‐Wei Wang Yao‐Kuang Wang Faming Zhang Yu‐Chung Su Jaw‐Yuan Wang Deng‐Chyang Wu Wen‐Hung Hsu |
author_sort |
Jiunn‐Wei Wang |
title |
Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series |
title_short |
Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series |
title_full |
Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series |
title_fullStr |
Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series |
title_full_unstemmed |
Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series |
title_sort |
initial experience of fecal microbiota transplantation in gastrointestinal disease: a case series |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X 2410-8650 |
publishDate |
2019-09-01 |
description |
Abstract Current studies have proven the strong association between gut microbiota dysbiosis and the pathogenesis of gastrointestinal diseases. Fecal microbiota transplantation (FMT) from a healthy donor is a promising therapeutic strategy to change and restore composition of the recipient's gut microbiota. Rapidly increasing clinical literatures confirmed the truth of the benefits of FMT on recurrent Clostridium difficile infection (rCDI) and inflammatory bowel disease. This article retrospectively reviewed nine cases (four cases had ulcerative colitis [UC], five cases had rCDI) who received FMT in Kaohsiung Medical University Hospital from April 2016 to November 2018. We summarized the procedure including donor selection, fecal materials preparation, transplantation delivery methods, and clinical outcomes. All of the four UC cases got clinical improvement and four rCDI cases achieved clinical remission after FMT. The other one rCDI case remained positive stool Toxin A+B result after FMT, and got remission after salvage treatment with fidaxomicin. FMT is considered to be a well‐tolerated adjuvant treatment for UC and effective salvage treatment for rCDI in our initial experience. Multiple infusions of FMT in UC and rCDI might have exceptional clinical efficiency, and enteral tube insertion could be a useful method to reach this goal and make multiple sessions of FMT easier. |
topic |
Clostridium difficile infection fecal microbiota transplantation inflammatory bowel disease transendoscopic enteral tubing |
url |
https://doi.org/10.1002/kjm2.12094 |
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