Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population
Abstract Background Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of many cardiovascular diseases, we investigated the relationship between...
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doaj-43b2f93d0da242f6bead6da8edf1c2812020-11-25T02:02:14ZengBMCBMC Neurology1471-23772019-04-011911610.1186/s12883-019-1285-7Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han populationNing Gao0Tie Guo1Han Luo2Guolong Tu3Fanglin Niu4Mengdan Yan5Ying Xia6Department of Neurosurgery, Affiliated Haikou Hospital of Xiangya Medical College in Central South UniversityThe First Affiliated Hospital of Zhengzhou UniversityDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya Medical College in Central South UniversityDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya Medical College in Central South UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of EducationKey Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of EducationDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya Medical College in Central South UniversityAbstract Background Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of many cardiovascular diseases, we investigated the relationship between single nucleotide polymorphisms (SNPs) in MMP-9 and the risk of Ischemic stroke (IS) in a southern Chinese Han population. Methods This study included 250 stroke patients and 250 healthy controls. Genotyping was performed using the Agena MassARRAY system, and chi-squared tests and genetic models were used to evaluate the associations between MMP-9 SNPs and the risk of IS. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age. Results Polymorphism rs3787268 was associated with increased the risk of IS. Specifically, the genotype “G/A” significantly correlated with IS risk in the co-dominant model [odds ratio (OR) = 1.62; 95% confidence interval (CI) = 1.10–2.41; p = 0.035)], while genotypes “G/A” and “A/A” may increase the risk of IS based on the dominant model (OR = 1.62; 95% CI = 1.12–2.35; p = 0.0097). This SNP was also significantly associated with IS risk in the log-additive model (OR = 1.33; 95% CI = 1.03–1.70; p = 0.026). Conversely, haplotype “C/G” appears to reduce the risk of IS (OR = 0.71; 95% CI = 0.54–0.95; p = 0.019). Conclusions Our study showed that the rs3787268 locus in the MMP-9 gene may increase risk of IS in a southern Chinese Han population and thus provide insight into the IS pathogenesis.http://link.springer.com/article/10.1186/s12883-019-1285-7Ischemic strokeMMP-9Case-control studySingle nucleotide polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ning Gao Tie Guo Han Luo Guolong Tu Fanglin Niu Mengdan Yan Ying Xia |
spellingShingle |
Ning Gao Tie Guo Han Luo Guolong Tu Fanglin Niu Mengdan Yan Ying Xia Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population BMC Neurology Ischemic stroke MMP-9 Case-control study Single nucleotide polymorphism |
author_facet |
Ning Gao Tie Guo Han Luo Guolong Tu Fanglin Niu Mengdan Yan Ying Xia |
author_sort |
Ning Gao |
title |
Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population |
title_short |
Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population |
title_full |
Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population |
title_fullStr |
Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population |
title_full_unstemmed |
Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population |
title_sort |
association of the mmp-9 polymorphism and ischemic stroke risk in southern chinese han population |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2019-04-01 |
description |
Abstract Background Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of many cardiovascular diseases, we investigated the relationship between single nucleotide polymorphisms (SNPs) in MMP-9 and the risk of Ischemic stroke (IS) in a southern Chinese Han population. Methods This study included 250 stroke patients and 250 healthy controls. Genotyping was performed using the Agena MassARRAY system, and chi-squared tests and genetic models were used to evaluate the associations between MMP-9 SNPs and the risk of IS. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age. Results Polymorphism rs3787268 was associated with increased the risk of IS. Specifically, the genotype “G/A” significantly correlated with IS risk in the co-dominant model [odds ratio (OR) = 1.62; 95% confidence interval (CI) = 1.10–2.41; p = 0.035)], while genotypes “G/A” and “A/A” may increase the risk of IS based on the dominant model (OR = 1.62; 95% CI = 1.12–2.35; p = 0.0097). This SNP was also significantly associated with IS risk in the log-additive model (OR = 1.33; 95% CI = 1.03–1.70; p = 0.026). Conversely, haplotype “C/G” appears to reduce the risk of IS (OR = 0.71; 95% CI = 0.54–0.95; p = 0.019). Conclusions Our study showed that the rs3787268 locus in the MMP-9 gene may increase risk of IS in a southern Chinese Han population and thus provide insight into the IS pathogenesis. |
topic |
Ischemic stroke MMP-9 Case-control study Single nucleotide polymorphism |
url |
http://link.springer.com/article/10.1186/s12883-019-1285-7 |
work_keys_str_mv |
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