Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis
Allergic disease is one of the most important and common health problems worldwide. We have previously demonstrated that a fig leaf-derived lactic acid bacterium <i>Lactobacillus</i> (<i>Lb.</i>) <i>paracasei</i> IJH-SONE68 produces a novel exopolysaccharide (EPS)...
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doaj-43bade6d0d2149d392f7ba6557ec8b3f2020-11-24T21:31:38ZengMDPI AGMolecules1420-30492019-08-012416297010.3390/molecules24162970molecules24162970Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact DermatitisMasafumi Noda0Nasrin Sultana1Ikue Hayashi2Mitsuhiro Fukamachi3Masanori Sugiyama4Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanCentral Research Laboratory, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanAsahi Kohsan Co., Ltd., Shinjuku 1-1-14, Shinjuku-ku, Tokyo 160-0022, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanAllergic disease is one of the most important and common health problems worldwide. We have previously demonstrated that a fig leaf-derived lactic acid bacterium <i>Lactobacillus</i> (<i>Lb.</i>) <i>paracasei</i> IJH-SONE68 produces a novel exopolysaccharide (EPS). Furthermore, we have shown that the EPS inhibits the catalytic activity of hyaluronidase (EC 3.2.1.36) promoting inflammatory reactions. To evaluate the anti-allergy and anti-inflammatory effects of the EPS, in the present study, we employed the picryl-chloride-induced delayed-type (type IV) allergy model mice, which is used to evaluate the contact dermatitis. Oral administration of the EPS was observed to reduce the ear swelling in the model mice. We also observed that the overexpression of ear interleukin-4 (T helper (Th) 2 cytokine) mRNA and the increase in serum immunoglobulin E (IgE) are repressed. However, the expression of interferon-γ (Th1 cytokine) was not accelerated in all of the allergen-challenged model mice. The improvement may be responsible for the Th2 downregulation rather than the Th1 upregulation. In addition, the symptom of immediate-type (type I) allergy model mice was improved by oral administration of the IJH-SONE68 cell (data not shown). We can conclude that the IJH-SONE68-derived EPS is useful to improve the type I and IV allergies including atopic dermatitis.https://www.mdpi.com/1420-3049/24/16/2970exopolysaccharide<i>Lactobacillus paracasei</i>contact dermatitislactic acid bacteria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masafumi Noda Nasrin Sultana Ikue Hayashi Mitsuhiro Fukamachi Masanori Sugiyama |
spellingShingle |
Masafumi Noda Nasrin Sultana Ikue Hayashi Mitsuhiro Fukamachi Masanori Sugiyama Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis Molecules exopolysaccharide <i>Lactobacillus paracasei</i> contact dermatitis lactic acid bacteria |
author_facet |
Masafumi Noda Nasrin Sultana Ikue Hayashi Mitsuhiro Fukamachi Masanori Sugiyama |
author_sort |
Masafumi Noda |
title |
Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis |
title_short |
Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis |
title_full |
Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis |
title_fullStr |
Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis |
title_full_unstemmed |
Exopolysaccharide Produced by <i>Lactobacillus paracasei</i> IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis |
title_sort |
exopolysaccharide produced by <i>lactobacillus paracasei</i> ijh-sone68 prevents and improves the picryl chloride-induced contact dermatitis |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-08-01 |
description |
Allergic disease is one of the most important and common health problems worldwide. We have previously demonstrated that a fig leaf-derived lactic acid bacterium <i>Lactobacillus</i> (<i>Lb.</i>) <i>paracasei</i> IJH-SONE68 produces a novel exopolysaccharide (EPS). Furthermore, we have shown that the EPS inhibits the catalytic activity of hyaluronidase (EC 3.2.1.36) promoting inflammatory reactions. To evaluate the anti-allergy and anti-inflammatory effects of the EPS, in the present study, we employed the picryl-chloride-induced delayed-type (type IV) allergy model mice, which is used to evaluate the contact dermatitis. Oral administration of the EPS was observed to reduce the ear swelling in the model mice. We also observed that the overexpression of ear interleukin-4 (T helper (Th) 2 cytokine) mRNA and the increase in serum immunoglobulin E (IgE) are repressed. However, the expression of interferon-γ (Th1 cytokine) was not accelerated in all of the allergen-challenged model mice. The improvement may be responsible for the Th2 downregulation rather than the Th1 upregulation. In addition, the symptom of immediate-type (type I) allergy model mice was improved by oral administration of the IJH-SONE68 cell (data not shown). We can conclude that the IJH-SONE68-derived EPS is useful to improve the type I and IV allergies including atopic dermatitis. |
topic |
exopolysaccharide <i>Lactobacillus paracasei</i> contact dermatitis lactic acid bacteria |
url |
https://www.mdpi.com/1420-3049/24/16/2970 |
work_keys_str_mv |
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