Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature
A 57-year-old Japanese man was admitted to the hospital with back pain and fever, multiple lung nodules, and abdominal aortic aneurysm (AAA). Laboratory tests performed at admission showed an increased proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) level. Video-associated thoracoscopic...
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doaj-43bb0a2d54b94945bab01512597ea9552020-11-25T00:18:44ZengHindawi LimitedCase Reports in Rheumatology2090-68892090-68972018-01-01201810.1155/2018/96828019682801Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the LiteratureNaoko Niimi0Tomoko Miyashita1Kana Tanji2Takuya Hirai3Kozo Watanabe4Keigo Ikeda5Shinji Morimoto6Iwao Sekigawa7Department of Anesthesia, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, JapanDepartment of Internal Medicine and Rheumatology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, JapanDepartment of Internal Medicine and Rheumatology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, JapanDepartment of Internal Medicine and Rheumatology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, JapanDepartment of Internal Medicine and Rheumatology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, JapanA 57-year-old Japanese man was admitted to the hospital with back pain and fever, multiple lung nodules, and abdominal aortic aneurysm (AAA). Laboratory tests performed at admission showed an increased proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) level. Video-associated thoracoscopic lung biopsy was performed; pathologic examination showed granulation tissue with necrosis and multinucleated giant cells. The diagnosis of granulomatosis with polyangiitis (GPA) was confirmed on the basis of the clinical presentation, laboratory findings, and lung biopsy. All symptoms were ameliorated, and the serum level of PR3-ANCA declined following treatment with prednisolone and cyclophosphamide. Although the association of GPA with AAA is rare, GPA may be included among the large vessel vasculitides that can give rise to aortic aneurysm.http://dx.doi.org/10.1155/2018/9682801 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Naoko Niimi Tomoko Miyashita Kana Tanji Takuya Hirai Kozo Watanabe Keigo Ikeda Shinji Morimoto Iwao Sekigawa |
spellingShingle |
Naoko Niimi Tomoko Miyashita Kana Tanji Takuya Hirai Kozo Watanabe Keigo Ikeda Shinji Morimoto Iwao Sekigawa Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature Case Reports in Rheumatology |
author_facet |
Naoko Niimi Tomoko Miyashita Kana Tanji Takuya Hirai Kozo Watanabe Keigo Ikeda Shinji Morimoto Iwao Sekigawa |
author_sort |
Naoko Niimi |
title |
Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature |
title_short |
Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature |
title_full |
Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature |
title_fullStr |
Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature |
title_full_unstemmed |
Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature |
title_sort |
aortic aneurysm as a complication of granulomatosis with polyangiitis successfully treated with prednisolone and cyclophosphamide: a case report and review of the literature |
publisher |
Hindawi Limited |
series |
Case Reports in Rheumatology |
issn |
2090-6889 2090-6897 |
publishDate |
2018-01-01 |
description |
A 57-year-old Japanese man was admitted to the hospital with back pain and fever, multiple lung nodules, and abdominal aortic aneurysm (AAA). Laboratory tests performed at admission showed an increased proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) level. Video-associated thoracoscopic lung biopsy was performed; pathologic examination showed granulation tissue with necrosis and multinucleated giant cells. The diagnosis of granulomatosis with polyangiitis (GPA) was confirmed on the basis of the clinical presentation, laboratory findings, and lung biopsy. All symptoms were ameliorated, and the serum level of PR3-ANCA declined following treatment with prednisolone and cyclophosphamide. Although the association of GPA with AAA is rare, GPA may be included among the large vessel vasculitides that can give rise to aortic aneurysm. |
url |
http://dx.doi.org/10.1155/2018/9682801 |
work_keys_str_mv |
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