Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment Effect

Stroke is a serious worldwide medical condition that causes neurological function disability. Diffusional kurtosis imaging, which measures the non-Gaussianity of water diffusion, has been demonstrated to be a sensitive biomarker in many neuro-pathologies. This study explores the relationship between...

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Main Authors: C. Li, C. Lan, X. Zhang, L. Yin, X. Hao, J. Tian, L. Lin, H. Sun, Z. Yao, X. Feng, J. Jia, Y. Yang
Format: Article
Language:English
Published: SAGE Publishing 2019-08-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/0963689719837919
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spelling doaj-43bf1739f27d4cc0a3df831eab9d5e0c2020-11-25T03:56:36ZengSAGE PublishingCell Transplantation0963-68971555-38922019-08-012810.1177/0963689719837919Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment EffectC. Li0C. Lan1X. Zhang2L. Yin3X. Hao4J. Tian5L. Lin6H. Sun7Z. Yao8X. Feng9J. Jia10Y. Yang11 Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of Rehabilitation, Shanxi Dayi Hospital, Taiyuan, China Department of Radiotherapy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China Department of Radiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of Radiology, Renji Hospital, Shanghai Jiao Tong University, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Both the authors contributed equally to this article. Both the authors contributed equally to this article.Stroke is a serious worldwide medical condition that causes neurological function disability. Diffusional kurtosis imaging, which measures the non-Gaussianity of water diffusion, has been demonstrated to be a sensitive biomarker in many neuro-pathologies. This study explores the relationship between neural function recovery and transformation of the ischemic lesion and/or corticospinal tract during the sub-acute phase after stroke by using diffusional kurtosis imaging. We performed a prospective study of function recovery and K metrics of 43 patients with sub-acute ischemic stroke in the middle cerebral artery territory. The effect of rehabilitation treatment was evaluated using both the Fugl-Meyer motor function score and modified Barthel index score at post-treatment compared with admission, and patients were allocated to two groups: good and poor rehabilitation effect (GRE and PRE). Metrics of diffusional kurtosis imaging within ischemic lesion and along the corticospinal tract were acquired, respectively. All three relative axial diffusional kurtoses (rKas) along the corticospinal tract in the GRE group ( n = 21) were significantly larger than those of the PRE group ( n = 22), including rKa in the posterior limb of internal capsule, rKa in the cerebral peduncle, and rKa in the basal part of the pons ( p = 0.014, 0.005, and 0.021, respectively). This multi-parametric magnetic resonance imaging study showed that diffusional kurtosis imaging has the potential to complement existing stroke imaging techniques and revealed its own advantages in elucidating the possible biophysical mechanism of functional restoration underlying ischemic stroke.https://doi.org/10.1177/0963689719837919
collection DOAJ
language English
format Article
sources DOAJ
author C. Li
C. Lan
X. Zhang
L. Yin
X. Hao
J. Tian
L. Lin
H. Sun
Z. Yao
X. Feng
J. Jia
Y. Yang
spellingShingle C. Li
C. Lan
X. Zhang
L. Yin
X. Hao
J. Tian
L. Lin
H. Sun
Z. Yao
X. Feng
J. Jia
Y. Yang
Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment Effect
Cell Transplantation
author_facet C. Li
C. Lan
X. Zhang
L. Yin
X. Hao
J. Tian
L. Lin
H. Sun
Z. Yao
X. Feng
J. Jia
Y. Yang
author_sort C. Li
title Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment Effect
title_short Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment Effect
title_full Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment Effect
title_fullStr Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment Effect
title_full_unstemmed Evaluation of Diffusional Kurtosis Imaging in Sub-acute Ischemic Stroke: Comparison with Rehabilitation Treatment Effect
title_sort evaluation of diffusional kurtosis imaging in sub-acute ischemic stroke: comparison with rehabilitation treatment effect
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 2019-08-01
description Stroke is a serious worldwide medical condition that causes neurological function disability. Diffusional kurtosis imaging, which measures the non-Gaussianity of water diffusion, has been demonstrated to be a sensitive biomarker in many neuro-pathologies. This study explores the relationship between neural function recovery and transformation of the ischemic lesion and/or corticospinal tract during the sub-acute phase after stroke by using diffusional kurtosis imaging. We performed a prospective study of function recovery and K metrics of 43 patients with sub-acute ischemic stroke in the middle cerebral artery territory. The effect of rehabilitation treatment was evaluated using both the Fugl-Meyer motor function score and modified Barthel index score at post-treatment compared with admission, and patients were allocated to two groups: good and poor rehabilitation effect (GRE and PRE). Metrics of diffusional kurtosis imaging within ischemic lesion and along the corticospinal tract were acquired, respectively. All three relative axial diffusional kurtoses (rKas) along the corticospinal tract in the GRE group ( n = 21) were significantly larger than those of the PRE group ( n = 22), including rKa in the posterior limb of internal capsule, rKa in the cerebral peduncle, and rKa in the basal part of the pons ( p = 0.014, 0.005, and 0.021, respectively). This multi-parametric magnetic resonance imaging study showed that diffusional kurtosis imaging has the potential to complement existing stroke imaging techniques and revealed its own advantages in elucidating the possible biophysical mechanism of functional restoration underlying ischemic stroke.
url https://doi.org/10.1177/0963689719837919
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