Autophagy: a new target for nonalcoholic fatty liver disease therapy
Yuqing Mao,1 Fujun Yu,1 Jianbo Wang,2 Chuanyong Guo,3 Xiaoming Fan1 1Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai, 2Department of Gastroenterology and Hepatology, The Central Hospital of Lishui City, Wenzhou Medical University, Zhejiang, 3Department o...
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doaj-43c0996ee8ac44409b83bf36210489ed2020-11-24T21:57:53ZengDove Medical PressHepatic Medicine : Evidence and Research1179-15352016-03-012016Issue 1273726153Autophagy: a new target for nonalcoholic fatty liver disease therapyMao YQYu FJWang JBGuo CYFan XMYuqing Mao,1 Fujun Yu,1 Jianbo Wang,2 Chuanyong Guo,3 Xiaoming Fan1 1Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai, 2Department of Gastroenterology and Hepatology, The Central Hospital of Lishui City, Wenzhou Medical University, Zhejiang, 3Department of Gastroenterology and Hepatology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, People's Republic of China Abstract: Nonalcoholic fatty liver disease (NAFLD) has gained importance in recent decades due to drastic changes in diet, especially in Western countries. NAFLD occurs as a spectrum from simple hepatic steatosis, steatohepatitis to cirrhosis, and even hepatocellular carcinoma. Although the molecular mechanisms underlying the development of NAFLD have been intensively investigated, many issues remain to be resolved. Autophagy is a cell survival mechanism for disposing of excess or defective organelles, and has become a hot spot for research. Recent studies have revealed that autophagy is linked to the development of NAFLD and regulation of autophagy has therapeutic potential. Autophagy reduces intracellular lipid droplets by enclosing them and fusing with lysosomes for degradation. Furthermore, autophagy is involved in attenuating inflammation and liver injury. However, autophagy is regarded as a double-edged sword, as it may also affect adipogenesis and adipocyte differentiation. Moreover, it is unclear as to whether autophagy protects the body from injury or causes diseases and even death, and the association between autophagy and NAFLD remains controversial. This review is intended to discuss, comment, and outline the progress made in this field and establish the possible molecular mechanism involved. Keywords: nonalcoholic fatty liver disease, autophagy, steatosis, steatohepatitis, fibrosis, carcinogenesishttps://www.dovepress.com/autophagy-a-new-target-for-nonalcoholic-fatty-liver-disease-therapy-peer-reviewed-article-HMERnonalcoholic fatty liver diseaseautophagysteatosissteatohepatitisfibrosiscarcinogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mao YQ Yu FJ Wang JB Guo CY Fan XM |
spellingShingle |
Mao YQ Yu FJ Wang JB Guo CY Fan XM Autophagy: a new target for nonalcoholic fatty liver disease therapy Hepatic Medicine : Evidence and Research nonalcoholic fatty liver disease autophagy steatosis steatohepatitis fibrosis carcinogenesis |
author_facet |
Mao YQ Yu FJ Wang JB Guo CY Fan XM |
author_sort |
Mao YQ |
title |
Autophagy: a new target for nonalcoholic fatty liver disease therapy |
title_short |
Autophagy: a new target for nonalcoholic fatty liver disease therapy |
title_full |
Autophagy: a new target for nonalcoholic fatty liver disease therapy |
title_fullStr |
Autophagy: a new target for nonalcoholic fatty liver disease therapy |
title_full_unstemmed |
Autophagy: a new target for nonalcoholic fatty liver disease therapy |
title_sort |
autophagy: a new target for nonalcoholic fatty liver disease therapy |
publisher |
Dove Medical Press |
series |
Hepatic Medicine : Evidence and Research |
issn |
1179-1535 |
publishDate |
2016-03-01 |
description |
Yuqing Mao,1 Fujun Yu,1 Jianbo Wang,2 Chuanyong Guo,3 Xiaoming Fan1 1Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai, 2Department of Gastroenterology and Hepatology, The Central Hospital of Lishui City, Wenzhou Medical University, Zhejiang, 3Department of Gastroenterology and Hepatology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, People's Republic of China Abstract: Nonalcoholic fatty liver disease (NAFLD) has gained importance in recent decades due to drastic changes in diet, especially in Western countries. NAFLD occurs as a spectrum from simple hepatic steatosis, steatohepatitis to cirrhosis, and even hepatocellular carcinoma. Although the molecular mechanisms underlying the development of NAFLD have been intensively investigated, many issues remain to be resolved. Autophagy is a cell survival mechanism for disposing of excess or defective organelles, and has become a hot spot for research. Recent studies have revealed that autophagy is linked to the development of NAFLD and regulation of autophagy has therapeutic potential. Autophagy reduces intracellular lipid droplets by enclosing them and fusing with lysosomes for degradation. Furthermore, autophagy is involved in attenuating inflammation and liver injury. However, autophagy is regarded as a double-edged sword, as it may also affect adipogenesis and adipocyte differentiation. Moreover, it is unclear as to whether autophagy protects the body from injury or causes diseases and even death, and the association between autophagy and NAFLD remains controversial. This review is intended to discuss, comment, and outline the progress made in this field and establish the possible molecular mechanism involved. Keywords: nonalcoholic fatty liver disease, autophagy, steatosis, steatohepatitis, fibrosis, carcinogenesis |
topic |
nonalcoholic fatty liver disease autophagy steatosis steatohepatitis fibrosis carcinogenesis |
url |
https://www.dovepress.com/autophagy-a-new-target-for-nonalcoholic-fatty-liver-disease-therapy-peer-reviewed-article-HMER |
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