MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis
<p>Abstract</p> <p>Background</p> <p>Plaque imaging based on magnetic resonance imaging (MRI) represents a new modality for risk assessment in atherosclerosis. It allows classification of carotid plaques in high-risk and low-risk lesion types (I-VIII). Type 2 diabetes m...
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doaj-43c31e636435493787f1012d1e9bbc632020-11-25T00:29:57ZengBMCBMC Medical Imaging1471-23422010-11-011012710.1186/1471-2342-10-27MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosisHolzer KLiebig TWinkler CFeurer RSepp DPelisek JaroslavBockelbrink AngelinaHeider PSaam TEsposito LPauly OSadikovic SHemmer BPoppert H<p>Abstract</p> <p>Background</p> <p>Plaque imaging based on magnetic resonance imaging (MRI) represents a new modality for risk assessment in atherosclerosis. It allows classification of carotid plaques in high-risk and low-risk lesion types (I-VIII). Type 2 diabetes mellitus (DM 2) represents a known risk factor for atherosclerosis, but its specific influence on plaque vulnerability is not fully understood. This study investigates whether MRI-plaque imaging can reveal differences in carotid plaque features of diabetic patients compared to nondiabetics.</p> <p>Methods</p> <p>191 patients with moderate to high-grade carotid artery stenosis were enrolled after written informed consent was obtained. Each patient underwent MRI-plaque imaging using a 1.5-T scanner with phased-array carotid coils. The carotid plaques were classified as lesion types I-VIII according to the MRI-modified AHA criteria. For 36 patients histology data was available.</p> <p>Results</p> <p>Eleven patients were excluded because of insufficient MR-image quality. DM 2 was diagnosed in 51 patients (28.3%). Concordance between histology and MRI-classification was 91.7% (33/36) and showed a Cohen's kappa value of 0.81 with a 95% CI of 0.98-1.15. MRI-defined high-risk lesion types were overrepresented in diabetic patients (n = 29; 56.8%). Multiple logistic regression analysis revealed association between DM 2 and MRI-defined high-risk lesion types (OR 2.59; 95% CI [1.15-5.81]), independent of the degree of stenosis.</p> <p>Conclusion</p> <p>DM 2 seems to represent a predictor for the development of vulnerable carotid plaques irrespective of the degree of stenosis and other risk factors. MRI-plaque imaging represents a new tool for risk stratification of diabetic patients.</p> <p>See Commentary: <url>http://www.biomedcentral.com/1741-7015/8/78/abstract</url></p> http://www.biomedcentral.com/1471-2342/10/27 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Holzer K Liebig T Winkler C Feurer R Sepp D Pelisek Jaroslav Bockelbrink Angelina Heider P Saam T Esposito L Pauly O Sadikovic S Hemmer B Poppert H |
spellingShingle |
Holzer K Liebig T Winkler C Feurer R Sepp D Pelisek Jaroslav Bockelbrink Angelina Heider P Saam T Esposito L Pauly O Sadikovic S Hemmer B Poppert H MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis BMC Medical Imaging |
author_facet |
Holzer K Liebig T Winkler C Feurer R Sepp D Pelisek Jaroslav Bockelbrink Angelina Heider P Saam T Esposito L Pauly O Sadikovic S Hemmer B Poppert H |
author_sort |
Holzer K |
title |
MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis |
title_short |
MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis |
title_full |
MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis |
title_fullStr |
MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis |
title_full_unstemmed |
MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis |
title_sort |
mri plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis |
publisher |
BMC |
series |
BMC Medical Imaging |
issn |
1471-2342 |
publishDate |
2010-11-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Plaque imaging based on magnetic resonance imaging (MRI) represents a new modality for risk assessment in atherosclerosis. It allows classification of carotid plaques in high-risk and low-risk lesion types (I-VIII). Type 2 diabetes mellitus (DM 2) represents a known risk factor for atherosclerosis, but its specific influence on plaque vulnerability is not fully understood. This study investigates whether MRI-plaque imaging can reveal differences in carotid plaque features of diabetic patients compared to nondiabetics.</p> <p>Methods</p> <p>191 patients with moderate to high-grade carotid artery stenosis were enrolled after written informed consent was obtained. Each patient underwent MRI-plaque imaging using a 1.5-T scanner with phased-array carotid coils. The carotid plaques were classified as lesion types I-VIII according to the MRI-modified AHA criteria. For 36 patients histology data was available.</p> <p>Results</p> <p>Eleven patients were excluded because of insufficient MR-image quality. DM 2 was diagnosed in 51 patients (28.3%). Concordance between histology and MRI-classification was 91.7% (33/36) and showed a Cohen's kappa value of 0.81 with a 95% CI of 0.98-1.15. MRI-defined high-risk lesion types were overrepresented in diabetic patients (n = 29; 56.8%). Multiple logistic regression analysis revealed association between DM 2 and MRI-defined high-risk lesion types (OR 2.59; 95% CI [1.15-5.81]), independent of the degree of stenosis.</p> <p>Conclusion</p> <p>DM 2 seems to represent a predictor for the development of vulnerable carotid plaques irrespective of the degree of stenosis and other risk factors. MRI-plaque imaging represents a new tool for risk stratification of diabetic patients.</p> <p>See Commentary: <url>http://www.biomedcentral.com/1741-7015/8/78/abstract</url></p> |
url |
http://www.biomedcentral.com/1471-2342/10/27 |
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