Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa
Traditionally and scientifically, research has shown that Orthosiphon aristatus and Oryza sativa L. var. glutinosa have antidiabetic activity. The combination of two medicinal plants can increase their biological activity. This study aimed to determine the antidiabetic activity of O. aristatus and O...
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Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya
2021-08-01
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doaj-43c467cefd91437b87b0214a40b442f22021-09-01T02:35:03ZengInstitute for Researches and Community Services Universitas Muhammadiyah Palangkaraya Borneo Journal of Pharmacy2621-48142021-08-014310.33084/bjop.v4i3.2154Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosaEris Septiana0Nurul Maulida Rizka1Yadi Yadi2Partomuan Simanjuntak3Indonesian Institute of SciencesUniversitas PancasilaIndonesian Institute of SciencesIndonesian Institute of SciencesTraditionally and scientifically, research has shown that Orthosiphon aristatus and Oryza sativa L. var. glutinosa have antidiabetic activity. The combination of two medicinal plants can increase their biological activity. This study aimed to determine the antidiabetic activity of O. aristatus and O. sativa L. var. glutinosa on single and combined extracts. Phytochemical screening of the single extract was done qualitatively. The α-glucosidase inhibitory method was used as an antidiabetic activity. The results showed that every extract contained alkaloids, steroids/triterpenoids, flavonoids, tannins, quinones, and coumarins. A single extract of O. sativa L. var glutinosa, O. aristatus, and their combinations (1:1, 1:2, and 2:1) had an α-glucosidase enzyme inhibitory activity with an IC50 value of 67.82, 80.93, 73.81, 88.72, and 61.51 µg/ml, respectively. The combination shows that the ratio of 1:1 was nearly additive, 1:2 was slight to moderate antagonism, and 2:1 was moderate to slight synergism. The combination of 96% ethanol extract of O. sativa L. var. glutinosa and O. aristatus in a ratio of 2:1 was the most effective in increasing its inhibitory activity. http://journal.umpalangkaraya.ac.id/index.php/bjop/article/view/2154α-glucosidaseAntidiabeticExtract combinationOryza sativa L. var. glutinosaOrthosiphon aristatus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eris Septiana Nurul Maulida Rizka Yadi Yadi Partomuan Simanjuntak |
spellingShingle |
Eris Septiana Nurul Maulida Rizka Yadi Yadi Partomuan Simanjuntak Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa Borneo Journal of Pharmacy α-glucosidase Antidiabetic Extract combination Oryza sativa L. var. glutinosa Orthosiphon aristatus |
author_facet |
Eris Septiana Nurul Maulida Rizka Yadi Yadi Partomuan Simanjuntak |
author_sort |
Eris Septiana |
title |
Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa |
title_short |
Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa |
title_full |
Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa |
title_fullStr |
Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa |
title_full_unstemmed |
Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa |
title_sort |
antidiabetic activity of extract combination of orthosiphon aristatus and oryza sativa l. var glutinosa |
publisher |
Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya |
series |
Borneo Journal of Pharmacy |
issn |
2621-4814 |
publishDate |
2021-08-01 |
description |
Traditionally and scientifically, research has shown that Orthosiphon aristatus and Oryza sativa L. var. glutinosa have antidiabetic activity. The combination of two medicinal plants can increase their biological activity. This study aimed to determine the antidiabetic activity of O. aristatus and O. sativa L. var. glutinosa on single and combined extracts. Phytochemical screening of the single extract was done qualitatively. The α-glucosidase inhibitory method was used as an antidiabetic activity. The results showed that every extract contained alkaloids, steroids/triterpenoids, flavonoids, tannins, quinones, and coumarins. A single extract of O. sativa L. var glutinosa, O. aristatus, and their combinations (1:1, 1:2, and 2:1) had an α-glucosidase enzyme inhibitory activity with an IC50 value of 67.82, 80.93, 73.81, 88.72, and 61.51 µg/ml, respectively. The combination shows that the ratio of 1:1 was nearly additive, 1:2 was slight to moderate antagonism, and 2:1 was moderate to slight synergism. The combination of 96% ethanol extract of O. sativa L. var. glutinosa and O. aristatus in a ratio of 2:1 was the most effective in increasing its inhibitory activity.
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topic |
α-glucosidase Antidiabetic Extract combination Oryza sativa L. var. glutinosa Orthosiphon aristatus |
url |
http://journal.umpalangkaraya.ac.id/index.php/bjop/article/view/2154 |
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