TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress...

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Main Authors: Rose Willett, José A. Martina, James P. Zewe, Rachel Wills, Gerald R. V. Hammond, Rosa Puertollano
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01871-z
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spelling doaj-43c5b38261d14c7e8511b4224b04b1322021-05-11T07:46:54ZengNature Publishing GroupNature Communications2041-17232017-11-018111710.1038/s41467-017-01871-zTFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomesRose Willett0José A. Martina1James P. Zewe2Rachel Wills3Gerald R. V. Hammond4Rosa Puertollano5Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of HealthCell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of HealthDepartment of Cell Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Room S332 Biomedical Sciences TowerDepartment of Cell Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Room S332 Biomedical Sciences TowerDepartment of Cell Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Room S332 Biomedical Sciences TowerCell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of HealthLysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress conditions.https://doi.org/10.1038/s41467-017-01871-z
collection DOAJ
language English
format Article
sources DOAJ
author Rose Willett
José A. Martina
James P. Zewe
Rachel Wills
Gerald R. V. Hammond
Rosa Puertollano
spellingShingle Rose Willett
José A. Martina
James P. Zewe
Rachel Wills
Gerald R. V. Hammond
Rosa Puertollano
TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
Nature Communications
author_facet Rose Willett
José A. Martina
James P. Zewe
Rachel Wills
Gerald R. V. Hammond
Rosa Puertollano
author_sort Rose Willett
title TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_short TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_full TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_fullStr TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_full_unstemmed TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
title_sort tfeb regulates lysosomal positioning by modulating tmem55b expression and jip4 recruitment to lysosomes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress conditions.
url https://doi.org/10.1038/s41467-017-01871-z
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