Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models
The purpose of this study was to investigate potential anti-gouty effect of astilbin (AS) and its possible mechanisms. In mice with hyperuricemia induced by potassium oxonate (OXO) and yeast extract powder (YEP), AS and febuxostat (FB) reduced the serum uric acid (UA) and xanthine oxidase (XO). More...
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Online Access: | https://doi.org/10.1515/chem-2020-0023 |
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doaj-43c76bf0e9a34d30b1e0421f2bd1d3982021-09-06T19:19:36ZengDe GruyterOpen Chemistry2391-54202020-04-0118120721410.1515/chem-2020-0023chem-2020-0023Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal ModelsYan Han0Li Lanzhou1Jiang Xue2Li Shaopeng3Chang Zecheng4Fei Xiaofang5Li Zhiping6Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun130012, ChinaKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun130012, ChinaKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun130012, ChinaKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun130012, ChinaSchool of Public Health, Jilin University, Changchun, Jilin 130012, ChinaKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun130012, ChinaKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun130012, ChinaThe purpose of this study was to investigate potential anti-gouty effect of astilbin (AS) and its possible mechanisms. In mice with hyperuricemia induced by potassium oxonate (OXO) and yeast extract powder (YEP), AS and febuxostat (FB) reduced the serum uric acid (UA) and xanthine oxidase (XO). Moreover, AS and FB reduced the levels of reactive oxygen species and increased the content of superoxide dismutase (SOD), glutathione peroxidase and catalase present in the serum. In acute gouty arthritis rats induced by intraarticular monosodium urate crystal injection, AS and Colchicine (COL) alleviated the ankle joints swelling, and reduced the inflammatory cell infiltration. AS also reduced the levels of interleukin 1β, interleukin 6, tumor necrosis factor alpha and monocyte chemoattractant protein 1 in liver. The present study first confirmed the anti-gouty effect of AS in mice with hyperuricemia and rats with acute gouty arthritis, which provides the experimental evidence for further evaluation of AS as a candidate for gout treatment.https://doi.org/10.1515/chem-2020-0023astilbinhyperuricemiaacute gouty arthritisinterleukin 1βxanthine oxidase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Han Li Lanzhou Jiang Xue Li Shaopeng Chang Zecheng Fei Xiaofang Li Zhiping |
spellingShingle |
Yan Han Li Lanzhou Jiang Xue Li Shaopeng Chang Zecheng Fei Xiaofang Li Zhiping Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models Open Chemistry astilbin hyperuricemia acute gouty arthritis interleukin 1β xanthine oxidase |
author_facet |
Yan Han Li Lanzhou Jiang Xue Li Shaopeng Chang Zecheng Fei Xiaofang Li Zhiping |
author_sort |
Yan Han |
title |
Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models |
title_short |
Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models |
title_full |
Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models |
title_fullStr |
Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models |
title_full_unstemmed |
Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models |
title_sort |
studies on the anti-gouty arthritis and anti-hyperuricemia properties of astilbin in animal models |
publisher |
De Gruyter |
series |
Open Chemistry |
issn |
2391-5420 |
publishDate |
2020-04-01 |
description |
The purpose of this study was to investigate potential anti-gouty effect of astilbin (AS) and its possible mechanisms. In mice with hyperuricemia induced by potassium oxonate (OXO) and yeast extract powder (YEP), AS and febuxostat (FB) reduced the serum uric acid (UA) and xanthine oxidase (XO). Moreover, AS and FB reduced the levels of reactive oxygen species and increased the content of superoxide dismutase (SOD), glutathione peroxidase and catalase present in the serum. In acute gouty arthritis rats induced by intraarticular monosodium urate crystal injection, AS and Colchicine (COL) alleviated the ankle joints swelling, and reduced the inflammatory cell infiltration. AS also reduced the levels of interleukin 1β, interleukin 6, tumor necrosis factor alpha and monocyte chemoattractant protein 1 in liver. The present study first confirmed the anti-gouty effect of AS in mice with hyperuricemia and rats with acute gouty arthritis, which provides the experimental evidence for further evaluation of AS as a candidate for gout treatment. |
topic |
astilbin hyperuricemia acute gouty arthritis interleukin 1β xanthine oxidase |
url |
https://doi.org/10.1515/chem-2020-0023 |
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