Protocol for a multi-centered, stepped wedge, cluster randomized controlled trial of the de-adoption of oral chlorhexidine prophylaxis and implementation of an oral care bundle for mechanically ventilated critically ill patients: the CHORAL study

Protocol for a multi-centered, stepped wedge, cluster randomized controlled trial of the de-adoption of oral chlorhexidine prophylaxis and implementation of an oral care bundle for mechanically ventilated critically ill patients: the CHORAL study

Abstract Background Routine application of chlorhexidine oral rinse is recommended to reduce risk of ventilator-associated pneumonia (VAP) in mechanically ventilated patients. Recent reappraisal of the evidence from two meta-analyses suggests chlorhexidine may cause excess mortality in non-cardiac s...

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Bibliographic Details
Main Authors: Craig M. Dale, Louise Rose, Sarah Carbone, Orla M. Smith, Lisa Burry, Eddy Fan, Andre Carlos Kajdacsy-Balla Amaral, Victoria A. McCredie, Ruxandra Pinto, Carlos R. Quiñonez, Susan Sutherland, Damon C. Scales, Brian H. Cuthbertson
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Trials
Subjects:
Chlorhexidine
Critical care
Ventilator-associated pneumonia
Oral care
Stepped-wedge cluster randomized controlled trial
Process evaluation
Online Access:http://link.springer.com/article/10.1186/s13063-019-3673-0

Internet

http://link.springer.com/article/10.1186/s13063-019-3673-0

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