Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer
Abstract Lung cancer is prone to metastasis to various organs. Although intraocular metastasis (IOM) occurs at a later stage than metastasis to other organs, it often adversely affects the quality of life and suggests a poor prognosis. In this study, we selected 1608 patients with lung cancer who ha...
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doaj-43ced6bcb8f1496ea71b6652c2c62f5f2020-11-25T03:53:15ZengWileyCancer Medicine2045-76342020-02-01941279128610.1002/cam4.2354Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancerQi Lin0Xuan‐Yin Chen1Wen‐Feng Liu2Pei‐Wen Zhu3Wen‐Qing Shi4Biao Li5Qing Yuan6You‐Lan Min7Jia‐Ming Liu8Yi Shao9Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaDepartment of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang Jiangxi People’s Republic of ChinaDepartment of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaDepartment of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaDepartment of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaDepartment of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaDepartment of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaDepartment of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaDepartment of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang Jiangxi People’s Republic of ChinaDepartment of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi People’s Republic of ChinaAbstract Lung cancer is prone to metastasis to various organs. Although intraocular metastasis (IOM) occurs at a later stage than metastasis to other organs, it often adversely affects the quality of life and suggests a poor prognosis. In this study, we selected 1608 patients with lung cancer who had metastasis to at least one site and explored clinical differences between those with IOM and non‐IOM (NIOM). An independent t test and chi‐squared test were used to analyze the clinical features of the patients. The statistically significant parameters were analyzed by binary logistic regression to determine the risk factors for IOM. A receiver operating characteristic curve was constructed to assess their diagnostic value in IOM. The results showed that no significant differences were noted in age, gender, and pathological type between the IOM and NIOM groups. However, the IOM group had higher levels of alpha‐fetoprotein, carcinoembryonic antigen, cancer antigen (CA)‐125, CA‐153, cytokeratin fragment 19 (CYFRA 21‐1), and total prostate‐specific antigen, compared with the NIOM group. Binary logistic regression indicated that CA‐153 and CYFRA 21‐1 were risk factors for IOM in patients with MLC (P < 0.05). Area under the curve of CA‐153, CYFRA 21‐1 and their combination were 0.791, 0.860, and 0.872 respectively. The cutoff values for CA‐153 and CYFRA 21‐1 were 22.2 U/mL and 6.785 ng/mL. In conclusion, both CA‐153 and CYFRA 21‐1 were independent risk factors for IOM in patients with metastatic lung cancer (MLC), whereas the combination of CA‐153 and CYFRA 21‐1 assessment yields the most value in the detection of IOM in patients with MLC.https://doi.org/10.1002/cam4.2354diagnostic valueintraocular metastasesmetastatic lung cancerrisk factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qi Lin Xuan‐Yin Chen Wen‐Feng Liu Pei‐Wen Zhu Wen‐Qing Shi Biao Li Qing Yuan You‐Lan Min Jia‐Ming Liu Yi Shao |
spellingShingle |
Qi Lin Xuan‐Yin Chen Wen‐Feng Liu Pei‐Wen Zhu Wen‐Qing Shi Biao Li Qing Yuan You‐Lan Min Jia‐Ming Liu Yi Shao Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer Cancer Medicine diagnostic value intraocular metastases metastatic lung cancer risk factors |
author_facet |
Qi Lin Xuan‐Yin Chen Wen‐Feng Liu Pei‐Wen Zhu Wen‐Qing Shi Biao Li Qing Yuan You‐Lan Min Jia‐Ming Liu Yi Shao |
author_sort |
Qi Lin |
title |
Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer |
title_short |
Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer |
title_full |
Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer |
title_fullStr |
Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer |
title_full_unstemmed |
Diagnostic value of CA‐153 and CYFRA 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer |
title_sort |
diagnostic value of ca‐153 and cyfra 21‐1 in predicting intraocular metastasis in patients with metastatic lung cancer |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2020-02-01 |
description |
Abstract Lung cancer is prone to metastasis to various organs. Although intraocular metastasis (IOM) occurs at a later stage than metastasis to other organs, it often adversely affects the quality of life and suggests a poor prognosis. In this study, we selected 1608 patients with lung cancer who had metastasis to at least one site and explored clinical differences between those with IOM and non‐IOM (NIOM). An independent t test and chi‐squared test were used to analyze the clinical features of the patients. The statistically significant parameters were analyzed by binary logistic regression to determine the risk factors for IOM. A receiver operating characteristic curve was constructed to assess their diagnostic value in IOM. The results showed that no significant differences were noted in age, gender, and pathological type between the IOM and NIOM groups. However, the IOM group had higher levels of alpha‐fetoprotein, carcinoembryonic antigen, cancer antigen (CA)‐125, CA‐153, cytokeratin fragment 19 (CYFRA 21‐1), and total prostate‐specific antigen, compared with the NIOM group. Binary logistic regression indicated that CA‐153 and CYFRA 21‐1 were risk factors for IOM in patients with MLC (P < 0.05). Area under the curve of CA‐153, CYFRA 21‐1 and their combination were 0.791, 0.860, and 0.872 respectively. The cutoff values for CA‐153 and CYFRA 21‐1 were 22.2 U/mL and 6.785 ng/mL. In conclusion, both CA‐153 and CYFRA 21‐1 were independent risk factors for IOM in patients with metastatic lung cancer (MLC), whereas the combination of CA‐153 and CYFRA 21‐1 assessment yields the most value in the detection of IOM in patients with MLC. |
topic |
diagnostic value intraocular metastases metastatic lung cancer risk factors |
url |
https://doi.org/10.1002/cam4.2354 |
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