Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular Carcinoma
Sections from 13 hepatocellular carcinomas (HCCs) were examined to determine the myofibroblasts (MFBs) in tumour fibrous stroma and cirrhotic fibrous stroma, using monoclonal antibodies to specific actins HHF-35, 1A4 and sarcomeric actin. Histological grading of tumours with the expression of a lab...
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Mahidol University
1999-01-01
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doaj-43d32389ac914d35a5c804370df4fea02021-08-13T10:11:20ZengMahidol UniversitySiriraj Medical Journal2228-80821999-01-01511Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular CarcinomaKanit Atisook0Mongkol Uiprasertkul1Prasit Watanapa2Jutamanee Ngernmesri3Nusara Wongwisitsak4Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University Sections from 13 hepatocellular carcinomas (HCCs) were examined to determine the myofibroblasts (MFBs) in tumour fibrous stroma and cirrhotic fibrous stroma, using monoclonal antibodies to specific actins HHF-35, 1A4 and sarcomeric actin. Histological grading of tumours with the expression of a labelling index using monoclonal antibodies to proliferative cell nuclear antigen (PC-10) were correlated with the amount of MFBs. The results showed a statistically significant increase in the amount of MFBs in tumour fibrous stroma. However, no significant correlation was found between the amount of MFBs with histological grading or the labelling index. However, a good correlation with statistically significant differences between the histological grading of HCC with the labelling index was shown. In conclusion, MFBs found in the tumour fibrous septa of HCC were a response by the stromal reaction or a desmoplastic reaction intended to limit the tumour size by contraction. https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246803- |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kanit Atisook Mongkol Uiprasertkul Prasit Watanapa Jutamanee Ngernmesri Nusara Wongwisitsak |
spellingShingle |
Kanit Atisook Mongkol Uiprasertkul Prasit Watanapa Jutamanee Ngernmesri Nusara Wongwisitsak Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular Carcinoma Siriraj Medical Journal - |
author_facet |
Kanit Atisook Mongkol Uiprasertkul Prasit Watanapa Jutamanee Ngernmesri Nusara Wongwisitsak |
author_sort |
Kanit Atisook |
title |
Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular Carcinoma |
title_short |
Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular Carcinoma |
title_full |
Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular Carcinoma |
title_fullStr |
Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular Carcinoma |
title_full_unstemmed |
Immunohistochemical and Ultrastructural Studies of Myofibroblasts in Hepatocellular Carcinoma |
title_sort |
immunohistochemical and ultrastructural studies of myofibroblasts in hepatocellular carcinoma |
publisher |
Mahidol University |
series |
Siriraj Medical Journal |
issn |
2228-8082 |
publishDate |
1999-01-01 |
description |
Sections from 13 hepatocellular carcinomas (HCCs) were examined to determine the myofibroblasts (MFBs) in tumour fibrous stroma and cirrhotic fibrous stroma, using monoclonal antibodies to specific actins HHF-35, 1A4 and sarcomeric actin. Histological grading of tumours with the expression of a labelling index using monoclonal antibodies to proliferative cell nuclear antigen (PC-10) were correlated with the amount of MFBs. The results showed a statistically significant increase in the amount of MFBs in tumour fibrous stroma. However, no significant correlation was found between the amount of MFBs with histological grading or the labelling index. However, a good correlation with statistically significant differences between the histological grading of HCC with the labelling index was shown. In conclusion, MFBs found in the tumour fibrous septa of HCC were a response by the stromal reaction or a desmoplastic reaction intended to limit the tumour size by contraction.
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topic |
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url |
https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246803 |
work_keys_str_mv |
AT kanitatisook immunohistochemicalandultrastructuralstudiesofmyofibroblastsinhepatocellularcarcinoma AT mongkoluiprasertkul immunohistochemicalandultrastructuralstudiesofmyofibroblastsinhepatocellularcarcinoma AT prasitwatanapa immunohistochemicalandultrastructuralstudiesofmyofibroblastsinhepatocellularcarcinoma AT jutamaneengernmesri immunohistochemicalandultrastructuralstudiesofmyofibroblastsinhepatocellularcarcinoma AT nusarawongwisitsak immunohistochemicalandultrastructuralstudiesofmyofibroblastsinhepatocellularcarcinoma |
_version_ |
1721208519638646784 |