Microencapsulated Neural Stem Cells Inhibit Sciatic Nerve Injury-Induced Pain by Reducing P2 × 4 Receptor Expression

Microencapsulated Neural Stem Cells Inhibit Sciatic Nerve Injury-Induced Pain by Reducing P2 × 4 Receptor Expression

Objectives: The purpose of this study is to investigate the effects of transplantation of microencapsulated neural stem cells (MC-NSCs), which downregulate the P2 × 4 receptor (P2 × 4R) overexpression and relieve neuropathic pain (NPP).Methods: Neural stem cells (NSCs) and MC-NSCs were transplanted...

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Bibliographic Details
Main Authors: Wen-jun Zhang, Chen Luo, Chao Huang, Si-cheng Liu, Hong-liang Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neural stem cells
neuropathic pain
P2 × 4 receptors
chronic sciatic nerve compression injury
microencapsulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.656780/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.656780/full

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