Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia

• Main Authors: Hataikarn Nimitphong, Sunee Saetung, La-or Chailurkit, Suwannee Chanprasertyothin, Boonsong Ongphiphadhanakul
• Format: Article
• Language: English
• Published: Elsevier 2021-03-01
• Series: Journal of Clinical & Translational Endocrinology
• Subjects: Vitamin D; Uric acid; Diabetes; Hyperuricaemia
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214623721000077

Aims: Vitamin D deficiency is associated with a number of noncommunicable conditions. We conducted a randomised controlled trial to determine the effect of vitamin D supplementation on serum uric acid concentration in patients with prediabetes, in whom hyperuricaemia is common. Methods: Seventy-one volunteers (35–80 years), with impaired fasting glucose and/or impaired glucose tolerance were randomised to three groups, vitamin D3, vitamin D2 and control, and followed for 12 months. Results: After 12 weeks, vitamin D supplementation was associated with a reduction in serum uric acid concentration in participants with baseline uric acid concentration > 6 mg/dL, but no significant change was observed in controls. We then assessed the dose–response relationship between vitamin D supplementation and the change in serum uric acid concentration and found that the change in serum total 25-hydroxyvitamin D did not correlate with the change in serum uric acid that occurred during vitamin D supplementation. The factors associated with larger reductions in serum uric acid were a higher baseline serum uric acid and a larger increase in serum 1,25-dihydroxyvitamin D. Conclusions: Vitamin D supplementation lowers serum uric acid in prediabetic patients with hyperuricaemia, and supplementation might be considered to help alleviate hyperuricaemia in these patients.