The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions

Cow's milk allergy is one of the most commonly reported childhood food allergies, with increasing incidence, persistence and severity in many countries across the world. The World Allergy Organization Special Committee on Food Allergy has identified cow's milk allergy as an area in need of...

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Main Authors:	Adam Fox, J. Andrew Bird, Alessandro Fiocchi, Jan Knol, Rosan Meyer, Seppo Salminen, Gong Sitang, Hania Szajewska, Nikolaos Papadopoulos
Format:	Article
Language:	English
Published:	Elsevier 2019-01-01
Series:	World Allergy Organization Journal
Online Access:	http://www.sciencedirect.com/science/article/pii/S1939455119303679

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spelling	doaj-43dd2d0753ef4e498c43f8a2044d0f032020-11-24T21:49:56ZengElsevierWorld Allergy Organization Journal1939-45512019-01-01125The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questionsAdam Fox0J. Andrew Bird1Alessandro Fiocchi2Jan Knol3Rosan Meyer4Seppo Salminen5Gong Sitang6Hania Szajewska7Nikolaos Papadopoulos8Dept of Paediatric Allergy, Guy’s & St Thomas’ Hospitals NHS Foundation Trust, Westminster Bridge, London SE1 7EH, United Kingdom; Corresponding author. Dept of Paediatric Allergy, Guy’s & St Thomas’ Hospitals NHS Foundation Trust, Westminster Bridge, London SE1 7EH, United Kingdom.University of Texas Southwestern Medical Center, Department of Pediatrics, Division of Allergy and Immunology, 5323 Harry Hines Blvd, Dallas, TX 75390-9063, USAAllergy Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, ItalyWageningen University, Stippeneng 4, 6708 WE Wageningen, the NetherlandsImperial College, Dept Paediatrics, London, UKFunctional Foods Forum, Faculty of Medicine, Itäinen pitkäkatu 4A, 20014 Turku, FinlandGuangzhou Women and Children's Medical Center, Tianhe, Guangzhou, 510620, ChinaDepartment of Paediatrics, The Medical University of Warsaw, 02-091 Warsaw, Zwiriki i Wigury 63A, PolandProfessor of Allergy & Paediatric Allergy Division of Infection, Immunity & Respiratory Medicine, University of Manchester, 5th Floor (Research), Royal Manchester Childrens Hospital, Manchester M13 9WL, UKCow's milk allergy is one of the most commonly reported childhood food allergies, with increasing incidence, persistence and severity in many countries across the world. The World Allergy Organization Special Committee on Food Allergy has identified cow's milk allergy as an area in need of a rationale-based approach in order to make progress against what it considered an onerous problem, with worldwide public health impact. There is growing interest in the potential role of the gut microbiota in the early programming and development of immune responses and allergy. This discussion paper considers the rationale and available evidence for modulation of the gut microbiota and for the use of synbiotics in the management of infants at risk of, or living with cow's milk allergy and summarizes remaining research questions that need to be answered for the development of evidence-based recommendations. Keywords: Cow's milk allergy, Allergy, Microbiota, Bifidobacteria, Lactobacilli, Synbiotic, Probiotic, Prebiotic, IgE, World Allergy Organization, Anaphylaxis, Dysbiosishttp://www.sciencedirect.com/science/article/pii/S1939455119303679
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Adam Fox J. Andrew Bird Alessandro Fiocchi Jan Knol Rosan Meyer Seppo Salminen Gong Sitang Hania Szajewska Nikolaos Papadopoulos
spellingShingle	Adam Fox J. Andrew Bird Alessandro Fiocchi Jan Knol Rosan Meyer Seppo Salminen Gong Sitang Hania Szajewska Nikolaos Papadopoulos The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions World Allergy Organization Journal
author_facet	Adam Fox J. Andrew Bird Alessandro Fiocchi Jan Knol Rosan Meyer Seppo Salminen Gong Sitang Hania Szajewska Nikolaos Papadopoulos
author_sort	Adam Fox
title	The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions
title_short	The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions
title_full	The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions
title_fullStr	The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions
title_full_unstemmed	The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions
title_sort	potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: an exploration of the rationale, available evidence and remaining questions
publisher	Elsevier
series	World Allergy Organization Journal
issn	1939-4551
publishDate	2019-01-01
description	Cow's milk allergy is one of the most commonly reported childhood food allergies, with increasing incidence, persistence and severity in many countries across the world. The World Allergy Organization Special Committee on Food Allergy has identified cow's milk allergy as an area in need of a rationale-based approach in order to make progress against what it considered an onerous problem, with worldwide public health impact. There is growing interest in the potential role of the gut microbiota in the early programming and development of immune responses and allergy. This discussion paper considers the rationale and available evidence for modulation of the gut microbiota and for the use of synbiotics in the management of infants at risk of, or living with cow's milk allergy and summarizes remaining research questions that need to be answered for the development of evidence-based recommendations. Keywords: Cow's milk allergy, Allergy, Microbiota, Bifidobacteria, Lactobacilli, Synbiotic, Probiotic, Prebiotic, IgE, World Allergy Organization, Anaphylaxis, Dysbiosis
url	http://www.sciencedirect.com/science/article/pii/S1939455119303679
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The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions

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