Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score
Abstract Background Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes. Paricalcitol supplementation affects calcium/phosphate homeostasis and may affect calcification propensity. To...
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doaj-43de48f2aaa343cc8df37dff9cf54efb2020-11-24T21:22:57ZengBMCBMC Nephrology1471-23692018-08-011911510.1186/s12882-018-1000-8Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity scoreAmin Ussif0Hege Pihlstrøm1Andreas Pasch2Hallvard Holdaas3Anders Hartmann4Knut Smerud5Anders Åsberg6Department of Transplantation Medicine, Oslo University Hospital RikshospitaletDepartment of Transplantation Medicine, Oslo University Hospital RikshospitaletCalciscon AGDepartment of Transplantation Medicine, Oslo University Hospital RikshospitaletDepartment of Transplantation Medicine, Oslo University Hospital RikshospitaletSmerud Medical Research International ASDepartment of Transplantation Medicine, Oslo University Hospital RikshospitaletAbstract Background Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes. Paricalcitol supplementation affects calcium/phosphate homeostasis and may affect calcification propensity. To assess this hypothesis we measured T50 in kidney transplant recipients participating in a randomized study comparing paricalcitol versus no treatment during the first year after kidney transplantation. Methods Stored serum samples from 76 kidney transplant recipients (paricalcitol n = 37, no treatment n = 39) were analyzed. Analyses were performed at inclusion (8 weeks after transplantation) and repeated one year after transplantation. Results There were no statistically significant differences in T50 between the paricalcitol and placebo groups, neither at baseline (p = 0.56) nor at 1 year (p = 0.61). Also, there were no significant changes in T50 over time in either group or when pooling all data (p < 0.20). In multivariate regression analysis, out of 16 potentially relevant covariates, comprising clinical and biochemical parameters, only plasma PTH and T50 at baseline were significantly correlated to T50 after one year. (p < 0.03 and p < 0.01, respectively). Conclusions Calcium propensity measured as T50 score remained unchanged with paricalcitol treatment in kidney transplant recipients, and was not changed over time during the study period of one year. Trial registration ClinicalTrials.gov, NCT01694160, registered 23 September 2012.http://link.springer.com/article/10.1186/s12882-018-1000-8ParicalcitolCalcification propensity scoreRandomized controlled trialRenal transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amin Ussif Hege Pihlstrøm Andreas Pasch Hallvard Holdaas Anders Hartmann Knut Smerud Anders Åsberg |
spellingShingle |
Amin Ussif Hege Pihlstrøm Andreas Pasch Hallvard Holdaas Anders Hartmann Knut Smerud Anders Åsberg Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score BMC Nephrology Paricalcitol Calcification propensity score Randomized controlled trial Renal transplantation |
author_facet |
Amin Ussif Hege Pihlstrøm Andreas Pasch Hallvard Holdaas Anders Hartmann Knut Smerud Anders Åsberg |
author_sort |
Amin Ussif |
title |
Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score |
title_short |
Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score |
title_full |
Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score |
title_fullStr |
Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score |
title_full_unstemmed |
Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score |
title_sort |
paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2018-08-01 |
description |
Abstract Background Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes. Paricalcitol supplementation affects calcium/phosphate homeostasis and may affect calcification propensity. To assess this hypothesis we measured T50 in kidney transplant recipients participating in a randomized study comparing paricalcitol versus no treatment during the first year after kidney transplantation. Methods Stored serum samples from 76 kidney transplant recipients (paricalcitol n = 37, no treatment n = 39) were analyzed. Analyses were performed at inclusion (8 weeks after transplantation) and repeated one year after transplantation. Results There were no statistically significant differences in T50 between the paricalcitol and placebo groups, neither at baseline (p = 0.56) nor at 1 year (p = 0.61). Also, there were no significant changes in T50 over time in either group or when pooling all data (p < 0.20). In multivariate regression analysis, out of 16 potentially relevant covariates, comprising clinical and biochemical parameters, only plasma PTH and T50 at baseline were significantly correlated to T50 after one year. (p < 0.03 and p < 0.01, respectively). Conclusions Calcium propensity measured as T50 score remained unchanged with paricalcitol treatment in kidney transplant recipients, and was not changed over time during the study period of one year. Trial registration ClinicalTrials.gov, NCT01694160, registered 23 September 2012. |
topic |
Paricalcitol Calcification propensity score Randomized controlled trial Renal transplantation |
url |
http://link.springer.com/article/10.1186/s12882-018-1000-8 |
work_keys_str_mv |
AT aminussif paricalcitolsupplementationduringthefirstyearafterkidneytransplantationdoesnotaffectcalcificationpropensityscore AT hegepihlstrøm paricalcitolsupplementationduringthefirstyearafterkidneytransplantationdoesnotaffectcalcificationpropensityscore AT andreaspasch paricalcitolsupplementationduringthefirstyearafterkidneytransplantationdoesnotaffectcalcificationpropensityscore AT hallvardholdaas paricalcitolsupplementationduringthefirstyearafterkidneytransplantationdoesnotaffectcalcificationpropensityscore AT andershartmann paricalcitolsupplementationduringthefirstyearafterkidneytransplantationdoesnotaffectcalcificationpropensityscore AT knutsmerud paricalcitolsupplementationduringthefirstyearafterkidneytransplantationdoesnotaffectcalcificationpropensityscore AT andersasberg paricalcitolsupplementationduringthefirstyearafterkidneytransplantationdoesnotaffectcalcificationpropensityscore |
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1725994231098507264 |