Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal Circulation
Objective: to evaluate the safety of using 7.2% NaCl/6% hydroxyethyl starch 200/0.5 solution to develop acute renal injury (ARI) in patients after aortocoronary bypass surgery (ACBS) under extracorporeal circulation (EC). Subjects and methods. This was a single-center prospective, randomized, single...
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Russian Academy of Medical Sciences
2013-10-01
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doaj-43df40b445684a0980c458fd97f5a1542021-07-28T21:21:54ZrusRussian Academy of Medical SciencesObŝaâ Reanimatologiâ1813-97792411-71102013-10-019510.15360/1813-9779-2013-5-3698Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal CirculationV. V. Lomivorotov0E. V. Fominsky1S. M. Efremov2V. A. Nepomnyashchikh3V. N. Lomivorotov4A. N. Shilova5A. M. Chernyavsky6Academician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationAcademician E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian FederationObjective: to evaluate the safety of using 7.2% NaCl/6% hydroxyethyl starch 200/0.5 solution to develop acute renal injury (ARI) in patients after aortocoronary bypass surgery (ACBS) under extracorporeal circulation (EC). Subjects and methods. This was a single-center prospective, randomized, single-blind clinical trial. The patients singly received either 7.2% NaCl/6% hydroxyethyl starch 200/0.5 solution (a NC/HES group, n=20) or 0.9% NaCl (a control group, n=20) in a dose of 4 ml/kg for 30 min after induction of anesthesia. The primary endpoint was the rate of ARI diagnosed according to the recommendations of the International Organization KRIGO (Kidney Disease: Improving Global Outcomes). The secondary endpoints were serum cystatin C (sCys С), and urinary neutrophil gelatinase-associated lipocalin (uNGAL). Results. The rate of ARI was comparable in both patient groups. Thus, ARI was found in 4 (20%) patients in the NC/HES group and in 6 (30%) cases in the control group (p=0.72). During the first two postoperative days, the peak concentration of creatinine was significantly lower in the NC/HES group (101 (range 94—107) ^l/l) than in the control one (117 (range 100—127) ^l/l) (p=0.02). That of sCys C was substantially lower in the NC/HES group (0.83 (range 0.73—0.89) mg/l) than in the control one (1.02 (range 0.88—1.15) mg/l) (p=0.001). The patients of the NC/HES group had comparable peak of uNGAL concentrations (33 (range 5—38) ng/ml) versus the controls (30 (range 21—50) ng/ml). Conclusion. The use of NC/HES does not cause any increase in the rate of ARI, increased renal injury, or a more significant decrease in glomerular filtration in patients after ACBS under EC. Key words: hypertonic solution, hydroxyethyl starch, acute renal injury, aortocoronary bypass surgery.https://www.reanimatology.com/rmt/article/view/98hypertonic solutionhydroxyethyl starchacute renal injuryaortocoronary bypass surgery |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
V. V. Lomivorotov E. V. Fominsky S. M. Efremov V. A. Nepomnyashchikh V. N. Lomivorotov A. N. Shilova A. M. Chernyavsky |
spellingShingle |
V. V. Lomivorotov E. V. Fominsky S. M. Efremov V. A. Nepomnyashchikh V. N. Lomivorotov A. N. Shilova A. M. Chernyavsky Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal Circulation Obŝaâ Reanimatologiâ hypertonic solution hydroxyethyl starch acute renal injury aortocoronary bypass surgery |
author_facet |
V. V. Lomivorotov E. V. Fominsky S. M. Efremov V. A. Nepomnyashchikh V. N. Lomivorotov A. N. Shilova A. M. Chernyavsky |
author_sort |
V. V. Lomivorotov |
title |
Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal Circulation |
title_short |
Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal Circulation |
title_full |
Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal Circulation |
title_fullStr |
Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal Circulation |
title_full_unstemmed |
Effect of 7.2% NaCl/6% Hydroxyethyl Starch 200/0.5 Solution on Renal Function during Surgery under Extracorporeal Circulation |
title_sort |
effect of 7.2% nacl/6% hydroxyethyl starch 200/0.5 solution on renal function during surgery under extracorporeal circulation |
publisher |
Russian Academy of Medical Sciences |
series |
Obŝaâ Reanimatologiâ |
issn |
1813-9779 2411-7110 |
publishDate |
2013-10-01 |
description |
Objective: to evaluate the safety of using 7.2% NaCl/6% hydroxyethyl starch 200/0.5 solution to develop acute renal injury (ARI) in patients after aortocoronary bypass surgery (ACBS) under extracorporeal circulation (EC). Subjects and methods. This was a single-center prospective, randomized, single-blind clinical trial. The patients singly received either 7.2% NaCl/6% hydroxyethyl starch 200/0.5 solution (a NC/HES group, n=20) or 0.9% NaCl (a control group, n=20) in a dose of 4 ml/kg for 30 min after induction of anesthesia. The primary endpoint was the rate of ARI diagnosed according to the recommendations of the International Organization KRIGO (Kidney Disease: Improving Global Outcomes). The secondary endpoints were serum cystatin C (sCys С), and urinary neutrophil gelatinase-associated lipocalin (uNGAL). Results. The rate of ARI was comparable in both patient groups. Thus, ARI was found in 4 (20%) patients in the NC/HES group and in 6 (30%) cases in the control group (p=0.72). During the first two postoperative days, the peak concentration of creatinine was significantly lower in the NC/HES group (101 (range 94—107) ^l/l) than in the control one (117 (range 100—127) ^l/l) (p=0.02). That of sCys C was substantially lower in the NC/HES group (0.83 (range 0.73—0.89) mg/l) than in the control one (1.02 (range 0.88—1.15) mg/l) (p=0.001). The patients of the NC/HES group had comparable peak of uNGAL concentrations (33 (range 5—38) ng/ml) versus the controls (30 (range 21—50) ng/ml). Conclusion. The use of NC/HES does not cause any increase in the rate of ARI, increased renal injury, or a more significant decrease in glomerular filtration in patients after ACBS under EC. Key words: hypertonic solution, hydroxyethyl starch, acute renal injury, aortocoronary bypass surgery. |
topic |
hypertonic solution hydroxyethyl starch acute renal injury aortocoronary bypass surgery |
url |
https://www.reanimatology.com/rmt/article/view/98 |
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